TY - JOUR
T1 - Phenotypic differences in the hemodynamic response during REM sleep in six strains of inbred mice
AU - Campen, Matthew J.
AU - Tagaito, Yugo
AU - Jenkins, Todd P.
AU - Smith, Philip L.
AU - Schwartz, Alan R.
AU - O'Donnell, Christopher P.
PY - 2003/1
Y1 - 2003/1
N2 - The pattern of cardiovascular changes that occur at nighttime can have an impact on morbidity and mortality. Rapid-eye-movement (REM) sleep, in particular, represents a period of increased risk due to marked cardiovascular instability. We hypothesized that genetic differences between inbred strains of mice would affect the phenotypic expression of cardiovascular responses that occur in REM sleep. We monitored polysomnography and arterial blood pressure (PSA) simultaneously in six inbred strains of mice as they naturally cycled through sleep/ wake states. Two strains elevated their PSA above non-REM (NREM) levels for 57.9 ± 6.6% (BALB/cJ) and 51.8 ± 8.4% (DBA/2J) of the REM period and exhibited a significant (P < 0.05) number of PSA surges greater than 10 mmHg (0.78 ± 0.36 surges/min for BALB/cJ; 0.63 ± 0.13 surges/min for DBA/2J). Despite similar PSA responses, the DBA/2J strain exhibited a decreased heart rate and the BALB/cJ strain exhibited an increased heart rate during REM sleep. The four other strains. (A/J, C57BL/6J, C3H/HeJ, and CBA/J) exhibited a significant hypotensive response associated with no change in heart rate in three of the strains and a significant decrease in heart rate in the A/J strain. The overall variability in PSA during REM sleep was significantly greater in the C3H/HeJ strain (26.8 ± 2.0 mmHg; P < 0.0125) compared with the other five strains. We conclude that genetic background contributes to the magnitude, variability, and arterial baroreceptor buffering capacity of cardiovascular responses during REM sleep.
AB - The pattern of cardiovascular changes that occur at nighttime can have an impact on morbidity and mortality. Rapid-eye-movement (REM) sleep, in particular, represents a period of increased risk due to marked cardiovascular instability. We hypothesized that genetic differences between inbred strains of mice would affect the phenotypic expression of cardiovascular responses that occur in REM sleep. We monitored polysomnography and arterial blood pressure (PSA) simultaneously in six inbred strains of mice as they naturally cycled through sleep/ wake states. Two strains elevated their PSA above non-REM (NREM) levels for 57.9 ± 6.6% (BALB/cJ) and 51.8 ± 8.4% (DBA/2J) of the REM period and exhibited a significant (P < 0.05) number of PSA surges greater than 10 mmHg (0.78 ± 0.36 surges/min for BALB/cJ; 0.63 ± 0.13 surges/min for DBA/2J). Despite similar PSA responses, the DBA/2J strain exhibited a decreased heart rate and the BALB/cJ strain exhibited an increased heart rate during REM sleep. The four other strains. (A/J, C57BL/6J, C3H/HeJ, and CBA/J) exhibited a significant hypotensive response associated with no change in heart rate in three of the strains and a significant decrease in heart rate in the A/J strain. The overall variability in PSA during REM sleep was significantly greater in the C3H/HeJ strain (26.8 ± 2.0 mmHg; P < 0.0125) compared with the other five strains. We conclude that genetic background contributes to the magnitude, variability, and arterial baroreceptor buffering capacity of cardiovascular responses during REM sleep.
KW - Arterial baroreceptors
KW - Autonomic function
KW - Genetic
KW - Heart rate
KW - Heart rate variability
KW - Non-rapid-eye-movement sleep
KW - Sympathetic nerve activity
KW - Systemic arterial blood pressure
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U2 - 10.1152/physiolgenomics.00031.2002
DO - 10.1152/physiolgenomics.00031.2002
M3 - Article
C2 - 12388788
AN - SCOPUS:0141816972
SN - 1531-2267
VL - 11
SP - 227
EP - 234
JO - Physiological Genomics
JF - Physiological Genomics
ER -