TY - JOUR
T1 - Phenotypic and genotypic characteristics of inflammatory bowel disease in french canadians
T2 - Comparison with a large North American repository
AU - Bhat, Mamatha
AU - Nguyen, Geoffrey C.
AU - Pare, Pierre
AU - Lahaie, Raymond
AU - Deslandres, Colette
AU - Bernard, Edmond Jean
AU - Aumais, Guy
AU - Jobin, Gilles
AU - Wild, Gary
AU - Cohen, Albert
AU - Langelier, Diane
AU - Brant, Steven
AU - Dassopoulos, Themistocles
AU - McGovern, Dermot
AU - Torres, Esther
AU - Duerr, Richard
AU - Regueiro, Miguel
AU - Silverberg, Mark S.
AU - Steinhart, Hillary
AU - Griffiths, Anne M.
AU - Elkadri, Abdul
AU - Cho, Judy
AU - Proctor, Deborah
AU - Goyette, Philippe
AU - Rioux, John
AU - Bitton, Alain
PY - 2009/9
Y1 - 2009/9
N2 - OBJECTIVES:Phenotype characteristics of inflammatory bowel disease (IBD) may differ significantly among ethnic subpopulations. The aim of this study was to characterize the IBD phenotype in French Canadians, the most prominent founder population in North America.METHODS:Using well-characterized phenotype data in the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)-IBD Genetics Consortium repository on patients with IBD, we compared phenotypic characteristics of 202 French Canadians with those of 1,287 other Caucasian patients. These included diagnosis, anatomical location, disease behavior, extraintestinal manifestations, surgical history, and family history of IBD.RESULTS:French-Canadian patients with Crohn's disease (CD) were less likely to have stricturing disease (11 vs. 21%, P0.005; odds ratio (OR): 0.45, 95% confidence interval (95% CI): 0.24-0.85). Using a stringent definition of ethnicity (three out of four grandparents being French Canadians, as opposed to self-report, n148), French Canadians had a tendency toward developing fistulizing CD (37 vs. 28%, P0.07), and there was an increased prevalence of sacroiliitis among those with IBD (4 vs. 2%, P0.045). Among French Canadians, the numbers of current smokers in CD (40 vs. 25%, P0.006) and former smokers in ulcerative colitis (UC) (35 vs. 20%, P0.03) were significantly higher. The prevalence of one of the three main variants of nucleotide-binding oligomerization domain containing 2 (NOD2) single-nucleotide polymorphisms (SNPs) among French-Canadian CD patients was 43.2%. The 3020insC SNP correlated with small bowel disease in French Canadians (75 vs. 0%, P0.006).CONCLUSIONS: French Canadians show an IBD phenotype profile distinct from other Caucasian IBD populations, with an accentuated association between smoking status and IBD. This unique profile may have implications regarding the need for a different approach to the management of IBD in this population.
AB - OBJECTIVES:Phenotype characteristics of inflammatory bowel disease (IBD) may differ significantly among ethnic subpopulations. The aim of this study was to characterize the IBD phenotype in French Canadians, the most prominent founder population in North America.METHODS:Using well-characterized phenotype data in the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)-IBD Genetics Consortium repository on patients with IBD, we compared phenotypic characteristics of 202 French Canadians with those of 1,287 other Caucasian patients. These included diagnosis, anatomical location, disease behavior, extraintestinal manifestations, surgical history, and family history of IBD.RESULTS:French-Canadian patients with Crohn's disease (CD) were less likely to have stricturing disease (11 vs. 21%, P0.005; odds ratio (OR): 0.45, 95% confidence interval (95% CI): 0.24-0.85). Using a stringent definition of ethnicity (three out of four grandparents being French Canadians, as opposed to self-report, n148), French Canadians had a tendency toward developing fistulizing CD (37 vs. 28%, P0.07), and there was an increased prevalence of sacroiliitis among those with IBD (4 vs. 2%, P0.045). Among French Canadians, the numbers of current smokers in CD (40 vs. 25%, P0.006) and former smokers in ulcerative colitis (UC) (35 vs. 20%, P0.03) were significantly higher. The prevalence of one of the three main variants of nucleotide-binding oligomerization domain containing 2 (NOD2) single-nucleotide polymorphisms (SNPs) among French-Canadian CD patients was 43.2%. The 3020insC SNP correlated with small bowel disease in French Canadians (75 vs. 0%, P0.006).CONCLUSIONS: French Canadians show an IBD phenotype profile distinct from other Caucasian IBD populations, with an accentuated association between smoking status and IBD. This unique profile may have implications regarding the need for a different approach to the management of IBD in this population.
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U2 - 10.1038/ajg.2009.267
DO - 10.1038/ajg.2009.267
M3 - Article
C2 - 19513023
AN - SCOPUS:69949179487
SN - 0002-9270
VL - 104
SP - 2233
EP - 2240
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 9
ER -