Phenotypic and functional properties of m urine γδ T cell clones derived from malaria immunized, αβ T cell-deficient mice

Moriya Tsuji, Cassandra L. Eyster, Rebecca L. O'Brien, Willi K. Born, Mitali Bapna, Martin Reichel, Ruth S. Nussenzweig, Fidel Zavala

Research output: Contribution to journalArticle

Abstract

Six murine T cell clones expressing γδ TCR were generated from malaria immunized, αβ T cell-deficient mice. Phenotypic characterization of these clones has revealed that, in contrast to conventional αβ T cells, there is a considerable degree of heterogeneity among these 76 clones with regard to their surface markers and their lymphokine profile. One clone was found to display significant anti-parasite activity in vivo upon adoptive transfer. We attempted to determine whether the protective clone differs in one or more key characteristics from the non-protective clones. Although no obvious pattern peculiar to the protective 76 clone was observed, it appears that more than one parameter may, in combination, define a distinct protective phenotype, and thus explain the functional difference between the protective and non-protective γδ clones.

Original languageEnglish (US)
Pages (from-to)359-366
Number of pages8
JournalInternational Immunology
Volume8
Issue number3
DOIs
StatePublished - Jan 1 1996

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Keywords

  • Lipopolysaccharide
  • Lymphokine profile
  • Malaria
  • Murine γα T cells
  • Surface phenotype
  • TCR

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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