Phenotypic and functional properties of m urine γδ T cell clones derived from malaria immunized, αβ T cell-deficient mice

Moriya Tsuji, Cassandra L. Eyster, Rebecca L. O'Brien, Willi K. Born, Mitali Bapna, Martin Reichel, Ruth S. Nussenzweig, Fidel P Zavala

Research output: Contribution to journalArticle

Abstract

Six murine T cell clones expressing γδ TCR were generated from malaria immunized, αβ T cell-deficient mice. Phenotypic characterization of these clones has revealed that, in contrast to conventional αβ T cells, there is a considerable degree of heterogeneity among these 76 clones with regard to their surface markers and their lymphokine profile. One clone was found to display significant anti-parasite activity in vivo upon adoptive transfer. We attempted to determine whether the protective clone differs in one or more key characteristics from the non-protective clones. Although no obvious pattern peculiar to the protective 76 clone was observed, it appears that more than one parameter may, in combination, define a distinct protective phenotype, and thus explain the functional difference between the protective and non-protective γδ clones.

Original languageEnglish (US)
Pages (from-to)359-366
Number of pages8
JournalInternational Immunology
Volume8
Issue number3
StatePublished - 1996
Externally publishedYes

Fingerprint

Malaria
Clone Cells
Urine
T-Lymphocytes
Adoptive Transfer
Lymphokines
Parasites
Phenotype

Keywords

  • Lipopolysaccharide
  • Lymphokine profile
  • Malaria
  • Murine γα T cells
  • Surface phenotype
  • TCR

ASJC Scopus subject areas

  • Immunology

Cite this

Phenotypic and functional properties of m urine γδ T cell clones derived from malaria immunized, αβ T cell-deficient mice. / Tsuji, Moriya; Eyster, Cassandra L.; O'Brien, Rebecca L.; Born, Willi K.; Bapna, Mitali; Reichel, Martin; Nussenzweig, Ruth S.; Zavala, Fidel P.

In: International Immunology, Vol. 8, No. 3, 1996, p. 359-366.

Research output: Contribution to journalArticle

Tsuji, M, Eyster, CL, O'Brien, RL, Born, WK, Bapna, M, Reichel, M, Nussenzweig, RS & Zavala, FP 1996, 'Phenotypic and functional properties of m urine γδ T cell clones derived from malaria immunized, αβ T cell-deficient mice', International Immunology, vol. 8, no. 3, pp. 359-366.
Tsuji, Moriya ; Eyster, Cassandra L. ; O'Brien, Rebecca L. ; Born, Willi K. ; Bapna, Mitali ; Reichel, Martin ; Nussenzweig, Ruth S. ; Zavala, Fidel P. / Phenotypic and functional properties of m urine γδ T cell clones derived from malaria immunized, αβ T cell-deficient mice. In: International Immunology. 1996 ; Vol. 8, No. 3. pp. 359-366.
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AU - Reichel, Martin

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