Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations

Eric Spierings; Matthijs Hendriks; Léna Absi; Angelica Canossi; Sonal Chhaya; John Crowley; Harry Dolstra; Jean François Eliaou; Tom Ellis; Jürgen Enczmann; Maria E. Fasano; Thibaut Gervais; Clara Gorodezky; Brigitte Kircher; David Laurin; Mary S. Leffell; Pascale Loiseau; Mari Malkki; Miroslaw Markiewicz; Miryam Martinetti; Etsuko Maruya; Narinder Mehra; Fatma Oguz; Machteld Oudshoorn; Noemi Pereira; Rajni Rani; Ruhena Sergeant; Jackie Thomson; Hien Tran Thuong; Hannu Turpeinen; Kuo Liang Yang; Renata Zunec; Mary Carrington; Peter De Knijff; Els Goulmy

doi:10.1371/journal.pgen.0030103

Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations

Eric Spierings, Matthijs Hendriks, Léna Absi, Angelica Canossi, Sonal Chhaya, John Crowley, Harry Dolstra, Jean François Eliaou, Tom Ellis, Jürgen Enczmann, Maria E. Fasano, Thibaut Gervais, Clara Gorodezky, Brigitte Kircher, David Laurin, Mary S. Leffell, Pascale Loiseau, Mari Malkki, Miroslaw Markiewicz, Miryam MartinettiEtsuko Maruya, Narinder Mehra, Fatma Oguz, Machteld Oudshoorn, Noemi Pereira, Rajni Rani, Ruhena Sergeant, Jackie Thomson, Hien Tran Thuong, Hannu Turpeinen, Kuo Liang Yang, Renata Zunec, Mary Carrington, Peter De Knijff, Els Goulmy

School of Medicine

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

Minor histocompatibility (H) antigens are allogeneic target molecules having significant roles in alloimmune responses after human leukocyte antigen-matched solid organ and stem cell transplantation (SCT). Minor H antigens are instrumental in the processes of transplant rejection, graft-versus-host disease, and in the curative graft-versus-tumor effect of SCT. The latter characteristic enabled the current application of selected minor H antigens in clinical immunotherapeutic SCT protocols. No information exists on the global phenotypic distribution of the currently identified minor H antigens. Therefore, an estimation of their overall impact in human leukocyte antigen-matched solid organ and SCT in the major ethnic populations is still lacking. For the first time, a worldwide phenotype frequency analysis of ten autosomal minor H antigens was executed by 31 laboratories and comprised 2,685 randomly selected individuals from six major ethnic populations. Significant differences in minor H antigen frequencies were observed between the ethnic populations, some of which appeared to be geographically correlated.

Original language	English (US)
Pages (from-to)	1108-1119
Number of pages	12
Journal	PLoS genetics
Volume	3
Issue number	6
DOIs	https://doi.org/10.1371/journal.pgen.0030103
State	Published - Jun 2007

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Molecular Biology
Genetics
Genetics(clinical)
Cancer Research

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Spierings, E., Hendriks, M., Absi, L., Canossi, A., Chhaya, S., Crowley, J., Dolstra, H., Eliaou, J. F., Ellis, T., Enczmann, J., Fasano, M. E., Gervais, T., Gorodezky, C., Kircher, B., Laurin, D., Leffell, M. S., Loiseau, P., Malkki, M., Markiewicz, M., ... Goulmy, E. (2007). Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations. PLoS genetics, 3(6), 1108-1119. https://doi.org/10.1371/journal.pgen.0030103

Spierings, E, Hendriks, M, Absi, L, Canossi, A, Chhaya, S, Crowley, J, Dolstra, H, Eliaou, JF, Ellis, T, Enczmann, J, Fasano, ME, Gervais, T, Gorodezky, C, Kircher, B, Laurin, D, Leffell, MS, Loiseau, P, Malkki, M, Markiewicz, M, Martinetti, M, Maruya, E, Mehra, N, Oguz, F, Oudshoorn, M, Pereira, N, Rani, R, Sergeant, R, Thomson, J, Thuong, HT, Turpeinen, H, Yang, KL, Zunec, R, Carrington, M, De Knijff, P & Goulmy, E 2007, 'Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations', PLoS genetics, vol. 3, no. 6, pp. 1108-1119. https://doi.org/10.1371/journal.pgen.0030103

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title = "Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations",

abstract = "Minor histocompatibility (H) antigens are allogeneic target molecules having significant roles in alloimmune responses after human leukocyte antigen-matched solid organ and stem cell transplantation (SCT). Minor H antigens are instrumental in the processes of transplant rejection, graft-versus-host disease, and in the curative graft-versus-tumor effect of SCT. The latter characteristic enabled the current application of selected minor H antigens in clinical immunotherapeutic SCT protocols. No information exists on the global phenotypic distribution of the currently identified minor H antigens. Therefore, an estimation of their overall impact in human leukocyte antigen-matched solid organ and SCT in the major ethnic populations is still lacking. For the first time, a worldwide phenotype frequency analysis of ten autosomal minor H antigens was executed by 31 laboratories and comprised 2,685 randomly selected individuals from six major ethnic populations. Significant differences in minor H antigen frequencies were observed between the ethnic populations, some of which appeared to be geographically correlated.",

author = "Eric Spierings and Matthijs Hendriks and L{\'e}na Absi and Angelica Canossi and Sonal Chhaya and John Crowley and Harry Dolstra and Eliaou, {Jean Fran{\c c}ois} and Tom Ellis and J{\"u}rgen Enczmann and Fasano, {Maria E.} and Thibaut Gervais and Clara Gorodezky and Brigitte Kircher and David Laurin and Leffell, {Mary S.} and Pascale Loiseau and Mari Malkki and Miroslaw Markiewicz and Miryam Martinetti and Etsuko Maruya and Narinder Mehra and Fatma Oguz and Machteld Oudshoorn and Noemi Pereira and Rajni Rani and Ruhena Sergeant and Jackie Thomson and Thuong, {Hien Tran} and Hannu Turpeinen and Yang, {Kuo Liang} and Renata Zunec and Mary Carrington and {De Knijff}, Peter and Els Goulmy",

year = "2007",

month = jun,

doi = "10.1371/journal.pgen.0030103",

language = "English (US)",

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T1 - Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations

AU - Spierings, Eric

AU - Hendriks, Matthijs

AU - Absi, Léna

AU - Canossi, Angelica

AU - Chhaya, Sonal

AU - Crowley, John

AU - Dolstra, Harry

AU - Eliaou, Jean François

AU - Ellis, Tom

AU - Enczmann, Jürgen

AU - Fasano, Maria E.

AU - Gervais, Thibaut

AU - Gorodezky, Clara

AU - Kircher, Brigitte

AU - Laurin, David

AU - Leffell, Mary S.

AU - Loiseau, Pascale

AU - Malkki, Mari

AU - Markiewicz, Miroslaw

AU - Martinetti, Miryam

AU - Maruya, Etsuko

AU - Mehra, Narinder

AU - Oguz, Fatma

AU - Oudshoorn, Machteld

AU - Pereira, Noemi

AU - Rani, Rajni

AU - Sergeant, Ruhena

AU - Thomson, Jackie

AU - Thuong, Hien Tran

AU - Turpeinen, Hannu

AU - Yang, Kuo Liang

AU - Zunec, Renata

AU - Carrington, Mary

AU - De Knijff, Peter

AU - Goulmy, Els

PY - 2007/6

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N2 - Minor histocompatibility (H) antigens are allogeneic target molecules having significant roles in alloimmune responses after human leukocyte antigen-matched solid organ and stem cell transplantation (SCT). Minor H antigens are instrumental in the processes of transplant rejection, graft-versus-host disease, and in the curative graft-versus-tumor effect of SCT. The latter characteristic enabled the current application of selected minor H antigens in clinical immunotherapeutic SCT protocols. No information exists on the global phenotypic distribution of the currently identified minor H antigens. Therefore, an estimation of their overall impact in human leukocyte antigen-matched solid organ and SCT in the major ethnic populations is still lacking. For the first time, a worldwide phenotype frequency analysis of ten autosomal minor H antigens was executed by 31 laboratories and comprised 2,685 randomly selected individuals from six major ethnic populations. Significant differences in minor H antigen frequencies were observed between the ethnic populations, some of which appeared to be geographically correlated.

AB - Minor histocompatibility (H) antigens are allogeneic target molecules having significant roles in alloimmune responses after human leukocyte antigen-matched solid organ and stem cell transplantation (SCT). Minor H antigens are instrumental in the processes of transplant rejection, graft-versus-host disease, and in the curative graft-versus-tumor effect of SCT. The latter characteristic enabled the current application of selected minor H antigens in clinical immunotherapeutic SCT protocols. No information exists on the global phenotypic distribution of the currently identified minor H antigens. Therefore, an estimation of their overall impact in human leukocyte antigen-matched solid organ and SCT in the major ethnic populations is still lacking. For the first time, a worldwide phenotype frequency analysis of ten autosomal minor H antigens was executed by 31 laboratories and comprised 2,685 randomly selected individuals from six major ethnic populations. Significant differences in minor H antigen frequencies were observed between the ethnic populations, some of which appeared to be geographically correlated.

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Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations

Abstract

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