Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations.

Eric Spierings, Matthijs Hendriks, Léna Absi, Angelica Canossi, Sonal Chhaya, John Crowley, Harry Dolstra, Jean François Eliaou, Tom Ellis, Jürgen Enczmann, Maria E. Fasano, Thibaut Gervais, Clara Gorodezky, Brigitte Kircher, David Laurin, Mary S. Leffell, Pascale Loiseau, Mari Malkki, Miroslaw Markiewicz, Miryam MartinettiEtsuko Maruya, Narinder Mehra, Fatma Oguz, Machteld Oudshoorn, Noemi Pereira, Rajni Rani, Ruhena Sergeant, Jackie Thomson, Thuong Hien Tran, Hannu Turpeinen, Kuo Liang Yang, Renata Zunec, Mary Carrington, Peter de Knijff, Els Goulmy

Research output: Contribution to journalArticle

Abstract

Minor histocompatibility (H) antigens are allogeneic target molecules having significant roles in alloimmune responses after human leukocyte antigen-matched solid organ and stem cell transplantation (SCT). Minor H antigens are instrumental in the processes of transplant rejection, graft-versus-host disease, and in the curative graft-versus-tumor effect of SCT. The latter characteristic enabled the current application of selected minor H antigens in clinical immunotherapeutic SCT protocols. No information exists on the global phenotypic distribution of the currently identified minor H antigens. Therefore, an estimation of their overall impact in human leukocyte antigen-matched solid organ and SCT in the major ethnic populations is still lacking. For the first time, a worldwide phenotype frequency analysis of ten autosomal minor H antigens was executed by 31 laboratories and comprised 2,685 randomly selected individuals from six major ethnic populations. Significant differences in minor H antigen frequencies were observed between the ethnic populations, some of which appeared to be geographically correlated.

Original languageEnglish (US)
JournalPLoS Genetics
Volume3
Issue number6
DOIs
StatePublished - Jun 2007
Externally publishedYes

Fingerprint

histocompatibility antigens
Minor Histocompatibility Antigens
antigen
phenotype
cell transplantation
Stem Cell Transplantation
antigens
Phenotype
stem cells
transplantation
Population
HLA Antigens
graft rejection
Neoplastic Stem Cells
Graft Rejection
Graft vs Host Disease
H antigen
frequency analysis
tumor
Transplants

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Ecology, Evolution, Behavior and Systematics
  • Cancer Research
  • Genetics(clinical)

Cite this

Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations. / Spierings, Eric; Hendriks, Matthijs; Absi, Léna; Canossi, Angelica; Chhaya, Sonal; Crowley, John; Dolstra, Harry; Eliaou, Jean François; Ellis, Tom; Enczmann, Jürgen; Fasano, Maria E.; Gervais, Thibaut; Gorodezky, Clara; Kircher, Brigitte; Laurin, David; Leffell, Mary S.; Loiseau, Pascale; Malkki, Mari; Markiewicz, Miroslaw; Martinetti, Miryam; Maruya, Etsuko; Mehra, Narinder; Oguz, Fatma; Oudshoorn, Machteld; Pereira, Noemi; Rani, Rajni; Sergeant, Ruhena; Thomson, Jackie; Tran, Thuong Hien; Turpeinen, Hannu; Yang, Kuo Liang; Zunec, Renata; Carrington, Mary; de Knijff, Peter; Goulmy, Els.

In: PLoS Genetics, Vol. 3, No. 6, 06.2007.

Research output: Contribution to journalArticle

Spierings, E, Hendriks, M, Absi, L, Canossi, A, Chhaya, S, Crowley, J, Dolstra, H, Eliaou, JF, Ellis, T, Enczmann, J, Fasano, ME, Gervais, T, Gorodezky, C, Kircher, B, Laurin, D, Leffell, MS, Loiseau, P, Malkki, M, Markiewicz, M, Martinetti, M, Maruya, E, Mehra, N, Oguz, F, Oudshoorn, M, Pereira, N, Rani, R, Sergeant, R, Thomson, J, Tran, TH, Turpeinen, H, Yang, KL, Zunec, R, Carrington, M, de Knijff, P & Goulmy, E 2007, 'Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations.', PLoS Genetics, vol. 3, no. 6. https://doi.org/10.1371/journal.pgen.0030103
Spierings, Eric ; Hendriks, Matthijs ; Absi, Léna ; Canossi, Angelica ; Chhaya, Sonal ; Crowley, John ; Dolstra, Harry ; Eliaou, Jean François ; Ellis, Tom ; Enczmann, Jürgen ; Fasano, Maria E. ; Gervais, Thibaut ; Gorodezky, Clara ; Kircher, Brigitte ; Laurin, David ; Leffell, Mary S. ; Loiseau, Pascale ; Malkki, Mari ; Markiewicz, Miroslaw ; Martinetti, Miryam ; Maruya, Etsuko ; Mehra, Narinder ; Oguz, Fatma ; Oudshoorn, Machteld ; Pereira, Noemi ; Rani, Rajni ; Sergeant, Ruhena ; Thomson, Jackie ; Tran, Thuong Hien ; Turpeinen, Hannu ; Yang, Kuo Liang ; Zunec, Renata ; Carrington, Mary ; de Knijff, Peter ; Goulmy, Els. / Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations. In: PLoS Genetics. 2007 ; Vol. 3, No. 6.
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abstract = "Minor histocompatibility (H) antigens are allogeneic target molecules having significant roles in alloimmune responses after human leukocyte antigen-matched solid organ and stem cell transplantation (SCT). Minor H antigens are instrumental in the processes of transplant rejection, graft-versus-host disease, and in the curative graft-versus-tumor effect of SCT. The latter characteristic enabled the current application of selected minor H antigens in clinical immunotherapeutic SCT protocols. No information exists on the global phenotypic distribution of the currently identified minor H antigens. Therefore, an estimation of their overall impact in human leukocyte antigen-matched solid organ and SCT in the major ethnic populations is still lacking. For the first time, a worldwide phenotype frequency analysis of ten autosomal minor H antigens was executed by 31 laboratories and comprised 2,685 randomly selected individuals from six major ethnic populations. Significant differences in minor H antigen frequencies were observed between the ethnic populations, some of which appeared to be geographically correlated.",
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AU - Dolstra, Harry

AU - Eliaou, Jean François

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AU - Oudshoorn, Machteld

AU - Pereira, Noemi

AU - Rani, Rajni

AU - Sergeant, Ruhena

AU - Thomson, Jackie

AU - Tran, Thuong Hien

AU - Turpeinen, Hannu

AU - Yang, Kuo Liang

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