Phenotype and function of hematopoietic stem cells

Saul J. Sharkis, Sara Neutzel, Michael I. Collector

Research output: Contribution to journalArticlepeer-review

Abstract

Using an in vivo selection technique, we can isolate individual cells that can repopulate the hematopoietic system of a lethally irradiated murine recipient. These cells rapidly acquire a CD34 phenotype in the animal. Progenitors in our long-term chimeras are of donor type. We also have evidence that transplantation of limiting numbers (as low as a single cell) that have this long-term repopulating ability (LTRA) can self-renew. This is demonstrated by serial transplantation of marrow from engrafted recipients 11 months post transplant into new hosts for four additional months.

Original languageEnglish (US)
Pages (from-to)191-195
Number of pages5
JournalAnnals of the New York Academy of Sciences
Volume938
DOIs
StatePublished - 2001

Keywords

  • Self-renewal
  • Single stem cell transplantation
  • Stem cell homing

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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