Phenobarbital vs. phenytoin for grand mal epilepsy.

S. Livingston, L. L. Pauli, I. Pruce, I. I. Kramer

Research output: Contribution to journalArticlepeer-review


The chief side effect of phenobarbital is drowsiness, which is usually associated with overdosage. Phenytoin, on the other hand, causes gingival hyperplasia in many patients, irreversible hypertrichosis in some patients and lethal reactions, such as Stevens-Johnson syndrome, in a few patients. Antiepileptic therapy should always be started with one drug. Phenytoin is specifically contraindicated as the drug of first choice for infants, females (especially adolescents) and children receiving orthodontic treatment.

Original languageEnglish (US)
Pages (from-to)123-127
Number of pages5
JournalAmerican family physician
Issue number2
StatePublished - Aug 1 1980

ASJC Scopus subject areas

  • Family Practice


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