Phencyclidine binding to striatal cocaine receptors

M. J. Kuhar; J. W. Boja; E. J. Cone

doi:10.1016/0028-3908(90)90016-K

Phencyclidine binding to striatal cocaine receptors

M. J. Kuhar, J. W. Boja, E. J. Cone

School of Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

PCP and related compounds inhibit ³H-mazindol binding to the cocaine receptor on dopamine transporters. The relative potencies of these compounds are such that some of the behavioral effects of PCP could be related to its action at the cocaine receptor; however, the affinity of PCP at the cocaine site (K_i = 1.59 μM) is less than its affinity at its own receptor (K_i about 0.12 μM). More data will be needed to conclusively implicate the cocaine receptor in the action of PCP.

Original language	English (US)
Pages (from-to)	295-297
Number of pages	3
Journal	Neuropharmacology
Volume	29
Issue number	3
DOIs	https://doi.org/10.1016/0028-3908(90)90016-K
State	Published - Mar 1990

Keywords

PCP
cocaine
cocaine receptors

ASJC Scopus subject areas

Pharmacology
Cellular and Molecular Neuroscience

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10.1016/0028-3908(90)90016-K

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title = "Phencyclidine binding to striatal cocaine receptors",

abstract = "PCP and related compounds inhibit 3H-mazindol binding to the cocaine receptor on dopamine transporters. The relative potencies of these compounds are such that some of the behavioral effects of PCP could be related to its action at the cocaine receptor; however, the affinity of PCP at the cocaine site (Ki = 1.59 μM) is less than its affinity at its own receptor (Ki about 0.12 μM). More data will be needed to conclusively implicate the cocaine receptor in the action of PCP.",

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year = "1990",

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T1 - Phencyclidine binding to striatal cocaine receptors

AU - Kuhar, M. J.

AU - Boja, J. W.

AU - Cone, E. J.

PY - 1990/3

Y1 - 1990/3

N2 - PCP and related compounds inhibit 3H-mazindol binding to the cocaine receptor on dopamine transporters. The relative potencies of these compounds are such that some of the behavioral effects of PCP could be related to its action at the cocaine receptor; however, the affinity of PCP at the cocaine site (Ki = 1.59 μM) is less than its affinity at its own receptor (Ki about 0.12 μM). More data will be needed to conclusively implicate the cocaine receptor in the action of PCP.

AB - PCP and related compounds inhibit 3H-mazindol binding to the cocaine receptor on dopamine transporters. The relative potencies of these compounds are such that some of the behavioral effects of PCP could be related to its action at the cocaine receptor; however, the affinity of PCP at the cocaine site (Ki = 1.59 μM) is less than its affinity at its own receptor (Ki about 0.12 μM). More data will be needed to conclusively implicate the cocaine receptor in the action of PCP.

KW - PCP

KW - cocaine

KW - cocaine receptors

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Phencyclidine binding to striatal cocaine receptors

Abstract

Keywords

ASJC Scopus subject areas

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