Phencyclidine binding to striatal cocaine receptors

M. J. Kuhar, J. W. Boja, E. J. Cone

Research output: Contribution to journalArticle

Abstract

PCP and related compounds inhibit 3H-mazindol binding to the cocaine receptor on dopamine transporters. The relative potencies of these compounds are such that some of the behavioral effects of PCP could be related to its action at the cocaine receptor; however, the affinity of PCP at the cocaine site (Ki = 1.59 μM) is less than its affinity at its own receptor (Ki about 0.12 μM). More data will be needed to conclusively implicate the cocaine receptor in the action of PCP.

Original languageEnglish (US)
Pages (from-to)295-297
Number of pages3
JournalNeuropharmacology
Volume29
Issue number3
DOIs
StatePublished - Mar 1990

Keywords

  • PCP
  • cocaine
  • cocaine receptors

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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