Phased RF ablation in persistent atrial fibrillation

John Hummel, Gregory Michaud, Robert Hoyt, David Delurgio, Abdi Rasekh, Fred Kusumoto, Michael Giudici, Dan Dan, David Tschopp, Hugh Calkins, Lucas Boersma

Research output: Contribution to journalArticle

Abstract

Background Persistent and long-standing persistent atrial fibrillation (AF) often requires extensive and/or repeat radiofrequency (RF) ablation procedures. Objective The Tailored Treatment of Persistent Atrial Fibrillation (TTOP-AF) study assessed the effectiveness and safety of the phased RF system in a randomized controlled comparison of medical therapy against phased RF ablation for the management of persistent and long-standing persistent AF. Methods Patients who had failed at least 1 antiarrhythmic drug (AAD) were randomized (2:1) to ablation management (AM) or medical management (MM). AM patients were allowed up to 2 ablations. Index and retreatment procedures consisted of pulmonary vein isolation and ablation of complex fractionated atrial electrograms. MM patients received AAD changes and/or cardioversion. The primary end points of the TTOP-AF study included chronic effectiveness and safety at 6 months and acute safety within 7 days of ablation. Results At 6 months, a greater proportion of AM patients achieved effectiveness off AAD (77 of 138 [55.8%]) compared to MM patients (19 of 72 [26.4%]) (P

Original languageEnglish (US)
Pages (from-to)202-209
Number of pages8
JournalHeart Rhythm
Volume11
Issue number2
DOIs
StatePublished - Feb 2014

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Atrial Fibrillation
Anti-Arrhythmia Agents
Safety
Cardiac Electrophysiologic Techniques
Electric Countershock
Retreatment
Pulmonary Veins
Therapeutics

Keywords

  • Ablation
  • Atrial fibrillation
  • Persistent
  • Phased RF
  • TTOP

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Hummel, J., Michaud, G., Hoyt, R., Delurgio, D., Rasekh, A., Kusumoto, F., ... Boersma, L. (2014). Phased RF ablation in persistent atrial fibrillation. Heart Rhythm, 11(2), 202-209. https://doi.org/10.1016/j.hrthm.2013.11.009

Phased RF ablation in persistent atrial fibrillation. / Hummel, John; Michaud, Gregory; Hoyt, Robert; Delurgio, David; Rasekh, Abdi; Kusumoto, Fred; Giudici, Michael; Dan, Dan; Tschopp, David; Calkins, Hugh; Boersma, Lucas.

In: Heart Rhythm, Vol. 11, No. 2, 02.2014, p. 202-209.

Research output: Contribution to journalArticle

Hummel, J, Michaud, G, Hoyt, R, Delurgio, D, Rasekh, A, Kusumoto, F, Giudici, M, Dan, D, Tschopp, D, Calkins, H & Boersma, L 2014, 'Phased RF ablation in persistent atrial fibrillation', Heart Rhythm, vol. 11, no. 2, pp. 202-209. https://doi.org/10.1016/j.hrthm.2013.11.009
Hummel J, Michaud G, Hoyt R, Delurgio D, Rasekh A, Kusumoto F et al. Phased RF ablation in persistent atrial fibrillation. Heart Rhythm. 2014 Feb;11(2):202-209. https://doi.org/10.1016/j.hrthm.2013.11.009
Hummel, John ; Michaud, Gregory ; Hoyt, Robert ; Delurgio, David ; Rasekh, Abdi ; Kusumoto, Fred ; Giudici, Michael ; Dan, Dan ; Tschopp, David ; Calkins, Hugh ; Boersma, Lucas. / Phased RF ablation in persistent atrial fibrillation. In: Heart Rhythm. 2014 ; Vol. 11, No. 2. pp. 202-209.
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