Phase II trial of paclitaxel in patients with advanced colon cancer previously untreated with cytotoxic chemotherapy: An Eastern Cooperative Oncology Group trial (PA286)

Avi I. Einzig, Donna Neuberg, Peter H. Wiernik, Louise B. Grochow, Guillermo Ramirez, Peter J. O'Dwyer, Nicholas J. Petrelli

Research output: Contribution to journalArticle

Abstract

Paclitaxel was administered as a 24-h continuous infusion at 250 mg/m2 in this Phase II trial in patients with adenocarcinoma of the colon or rectum. Nineteen patients were evaluated for toxicity and 15 were assessable for response. There were no complete or partial responses, and toxicity present was primarily neutropenia. This study found that paclitaxel as a single agent does not have activity in adenocarcinoma of the colon or rectum.

Original languageEnglish (US)
Pages (from-to)750-754
Number of pages5
JournalAmerican Journal of Therapeutics
Volume3
Issue number11
DOIs
StatePublished - Nov 1996

Keywords

  • colon cancer
  • paclitaxel (Taxol)

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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