Phase II trial of gallium nitrate, amonafide and teniposide in metastatic non-small cell lung cancer - An Eastern Cooperative Oncology Group study (E2588)

Alex Y Chang, Z. Nora Tu, Julia L. Smith, Philip Bonomi, Thomas J. Smith, Peter H. Wiernik, Ronald Blum

Research output: Contribution to journalArticle

Abstract

Fifty-five patients with metastatic non-small cell lung cancer (NSCLC) were entered into this phase II randomized study for evaluating three new agents: gallium nitrate, amonafide and teniposide. The patients had to have ECOG performance status 0 or 1, no prior chemotherapy, and adequate hematological, hepatic and renal functions. Forty-seven patients were eligible and evaluable. Fourteen were randomized to receive gallium nitrate, 18 to amonafide and 15 to teniposide. Seventy-four percent of eligible patients were male. The majority of patients (89%) had an ECOG performance status 1. ECOG grade 4 toxicity occurred twice in patients on gallium nitrate, seven times on amonafide and 18 times on teniposide. The cause of death was attributed to amonafide in one patient (from sepsis) and to teniposide in two patients (due to infection and leukopenia). There was no objective response in all the patients entered. The overall survival times ranged from 2 weeks to 156 weeks with a median of 23 weeks. There were no survival differences among the three treatment arms. We conclude that gallium nitrate, amonafide and teniposide are inactive in metastatic NSCLC and do not warrant any further testing in this disease.

Original languageEnglish (US)
Pages (from-to)137-141
Number of pages5
JournalInvestigational New Drugs
Volume13
Issue number2
DOIs
StatePublished - Jun 1995
Externally publishedYes

Fingerprint

gallium nitrate
amonafide
Teniposide
Non-Small Cell Lung Carcinoma
Survival
Leukopenia

Keywords

  • amonafide
  • gallium nitrate
  • lung cancer
  • teniposide

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

Cite this

Phase II trial of gallium nitrate, amonafide and teniposide in metastatic non-small cell lung cancer - An Eastern Cooperative Oncology Group study (E2588). / Chang, Alex Y; Nora Tu, Z.; Smith, Julia L.; Bonomi, Philip; Smith, Thomas J.; Wiernik, Peter H.; Blum, Ronald.

In: Investigational New Drugs, Vol. 13, No. 2, 06.1995, p. 137-141.

Research output: Contribution to journalArticle

Chang, Alex Y ; Nora Tu, Z. ; Smith, Julia L. ; Bonomi, Philip ; Smith, Thomas J. ; Wiernik, Peter H. ; Blum, Ronald. / Phase II trial of gallium nitrate, amonafide and teniposide in metastatic non-small cell lung cancer - An Eastern Cooperative Oncology Group study (E2588). In: Investigational New Drugs. 1995 ; Vol. 13, No. 2. pp. 137-141.
@article{22f02d76f086470db15ea1abb752a940,
title = "Phase II trial of gallium nitrate, amonafide and teniposide in metastatic non-small cell lung cancer - An Eastern Cooperative Oncology Group study (E2588)",
abstract = "Fifty-five patients with metastatic non-small cell lung cancer (NSCLC) were entered into this phase II randomized study for evaluating three new agents: gallium nitrate, amonafide and teniposide. The patients had to have ECOG performance status 0 or 1, no prior chemotherapy, and adequate hematological, hepatic and renal functions. Forty-seven patients were eligible and evaluable. Fourteen were randomized to receive gallium nitrate, 18 to amonafide and 15 to teniposide. Seventy-four percent of eligible patients were male. The majority of patients (89{\%}) had an ECOG performance status 1. ECOG grade 4 toxicity occurred twice in patients on gallium nitrate, seven times on amonafide and 18 times on teniposide. The cause of death was attributed to amonafide in one patient (from sepsis) and to teniposide in two patients (due to infection and leukopenia). There was no objective response in all the patients entered. The overall survival times ranged from 2 weeks to 156 weeks with a median of 23 weeks. There were no survival differences among the three treatment arms. We conclude that gallium nitrate, amonafide and teniposide are inactive in metastatic NSCLC and do not warrant any further testing in this disease.",
keywords = "amonafide, gallium nitrate, lung cancer, teniposide",
author = "Chang, {Alex Y} and {Nora Tu}, Z. and Smith, {Julia L.} and Philip Bonomi and Smith, {Thomas J.} and Wiernik, {Peter H.} and Ronald Blum",
year = "1995",
month = "6",
doi = "10.1007/BF00872862",
language = "English (US)",
volume = "13",
pages = "137--141",
journal = "Investigational New Drugs",
issn = "0167-6997",
publisher = "Kluwer Academic Publishers",
number = "2",

}

TY - JOUR

T1 - Phase II trial of gallium nitrate, amonafide and teniposide in metastatic non-small cell lung cancer - An Eastern Cooperative Oncology Group study (E2588)

AU - Chang, Alex Y

AU - Nora Tu, Z.

AU - Smith, Julia L.

AU - Bonomi, Philip

AU - Smith, Thomas J.

AU - Wiernik, Peter H.

AU - Blum, Ronald

PY - 1995/6

Y1 - 1995/6

N2 - Fifty-five patients with metastatic non-small cell lung cancer (NSCLC) were entered into this phase II randomized study for evaluating three new agents: gallium nitrate, amonafide and teniposide. The patients had to have ECOG performance status 0 or 1, no prior chemotherapy, and adequate hematological, hepatic and renal functions. Forty-seven patients were eligible and evaluable. Fourteen were randomized to receive gallium nitrate, 18 to amonafide and 15 to teniposide. Seventy-four percent of eligible patients were male. The majority of patients (89%) had an ECOG performance status 1. ECOG grade 4 toxicity occurred twice in patients on gallium nitrate, seven times on amonafide and 18 times on teniposide. The cause of death was attributed to amonafide in one patient (from sepsis) and to teniposide in two patients (due to infection and leukopenia). There was no objective response in all the patients entered. The overall survival times ranged from 2 weeks to 156 weeks with a median of 23 weeks. There were no survival differences among the three treatment arms. We conclude that gallium nitrate, amonafide and teniposide are inactive in metastatic NSCLC and do not warrant any further testing in this disease.

AB - Fifty-five patients with metastatic non-small cell lung cancer (NSCLC) were entered into this phase II randomized study for evaluating three new agents: gallium nitrate, amonafide and teniposide. The patients had to have ECOG performance status 0 or 1, no prior chemotherapy, and adequate hematological, hepatic and renal functions. Forty-seven patients were eligible and evaluable. Fourteen were randomized to receive gallium nitrate, 18 to amonafide and 15 to teniposide. Seventy-four percent of eligible patients were male. The majority of patients (89%) had an ECOG performance status 1. ECOG grade 4 toxicity occurred twice in patients on gallium nitrate, seven times on amonafide and 18 times on teniposide. The cause of death was attributed to amonafide in one patient (from sepsis) and to teniposide in two patients (due to infection and leukopenia). There was no objective response in all the patients entered. The overall survival times ranged from 2 weeks to 156 weeks with a median of 23 weeks. There were no survival differences among the three treatment arms. We conclude that gallium nitrate, amonafide and teniposide are inactive in metastatic NSCLC and do not warrant any further testing in this disease.

KW - amonafide

KW - gallium nitrate

KW - lung cancer

KW - teniposide

UR - http://www.scopus.com/inward/record.url?scp=0028884910&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028884910&partnerID=8YFLogxK

U2 - 10.1007/BF00872862

DO - 10.1007/BF00872862

M3 - Article

VL - 13

SP - 137

EP - 141

JO - Investigational New Drugs

JF - Investigational New Drugs

SN - 0167-6997

IS - 2

ER -