TY - JOUR
T1 - Phase II trial of diaziquone (AZQ) in advanced malignant melanoma
AU - Høst, Herman
AU - Joss, Rudolf
AU - Pinedo, Herbert
AU - Bruntsch, Uta
AU - Cavalli, Franco
AU - Renard, Georgette
AU - Glabbeke, Martine6Van
AU - Rozencweig, Marcel
PY - 1983
Y1 - 1983
N2 - Forty-two evaluable patients with malignant melanoma received AZQ 27 mg/m2 i.v. every 4 weeks. In 5 patients with poor marrow reserve this dose was reduced to 20 mg/m2. Doses were rapidly escalated when no significant myelosuppression was encountered in previous courses. Twenty-five patients had received no prior chemotherapy. A single partial response was obtained for 3 months. Inconsistent myelosuppression was the main toxic effect in this trial. The median WBC and platelet nadirs were 3200/mm3 (900-19,500) and 105,000/mm3 (33,000-530,000) respectively. In 2 patients leukopenia was complicated by a transient episode of infection. One-third of the patients did not experience significant myelosuppression. Non-hematologic adverse reactions were generally mild to moderate and consisted of nausea and vomiting in 26 patients and alopecia in 1. It is concluded that at this dose schedule AZQ is ineffective against malignant melanoma.
AB - Forty-two evaluable patients with malignant melanoma received AZQ 27 mg/m2 i.v. every 4 weeks. In 5 patients with poor marrow reserve this dose was reduced to 20 mg/m2. Doses were rapidly escalated when no significant myelosuppression was encountered in previous courses. Twenty-five patients had received no prior chemotherapy. A single partial response was obtained for 3 months. Inconsistent myelosuppression was the main toxic effect in this trial. The median WBC and platelet nadirs were 3200/mm3 (900-19,500) and 105,000/mm3 (33,000-530,000) respectively. In 2 patients leukopenia was complicated by a transient episode of infection. One-third of the patients did not experience significant myelosuppression. Non-hematologic adverse reactions were generally mild to moderate and consisted of nausea and vomiting in 26 patients and alopecia in 1. It is concluded that at this dose schedule AZQ is ineffective against malignant melanoma.
UR - http://www.scopus.com/inward/record.url?scp=1242326362&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1242326362&partnerID=8YFLogxK
U2 - 10.1016/0277-5379(83)90430-3
DO - 10.1016/0277-5379(83)90430-3
M3 - Article
C2 - 6681775
AN - SCOPUS:1242326362
SN - 0277-5379
VL - 19
SP - 295
EP - 298
JO - European Journal of Cancer and Clinical Oncology
JF - European Journal of Cancer and Clinical Oncology
IS - 2
ER -