Phase II trial of combined radiotherapy and daily low-dose cisplatin for inoperable, locally advanced non-small cell lung cancer (NSCLC)

Gerrit Van Harskamp, Epie Boven, Jan B. Vermorken, Henk Van Deutekom, Jaap Stam, K. Hian Njo, A. B M F Karim, Anton H. Tierie, Richard P. Golding, Herbert M. Pinedo

Research output: Contribution to journalArticle

Abstract

With the use of cis-diamminedichloroplatinum(II), cisplatin, to enhance the effect of radiation a combined modality approach was designed to treat patients with inoperable, locally advanced NSCLC. The regimen consisted of radiation doses of 300 cGy for 4 days every week for 4 weeks with a 2 week split in between. Each radiation dose was followed by an i.v. injection of cisplatin 6 mg m2 within 30 min. Hydration consisted on an oral fluid intake of 2 L only, enabling the patient to receive the treatment on an outpatient basis. Of 40 patients entered into the study, 37 were evaluable for toxicity and 33 for response. Overall response rate was 65% and complete response rate 22%. Median duration of local control was 7 months. The majority of all patients (76%) eventually progressed at the primary tumor site, while in 16 patients relapse occurred in distant sites first. Median duration of overall survival was 10.5 months, whereas that of complete responders was 29.5 months. Generally, acute side effects were transient and did not require discontinuation of treatment. One patient presented with thrombocytopenia 4 weeks after treatment had been finished. His death of cerebral bleeding was likely to be related with his therapy-resistant malignancy. Of late side effects three patients showed disabling symptoms consisting of uncontrollable pulmonary infections in the presence of tumor in two patients, one patient had radiation myelopathy and another experienced vertebral collapse with distal paresis. The combination of radiation and daily low-dose cisplatin is a tolerable treatment modality with most benefit for patients reaching a complete remission. Intensification of the regimen is being planned in those patients with inoperable, locally advanced squamous cell lung cancer to reach a complete remission.

Original languageEnglish (US)
Pages (from-to)1735-1738
Number of pages4
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume13
Issue number11
DOIs
StatePublished - 1987
Externally publishedYes

Fingerprint

Non-Small Cell Lung Carcinoma
lungs
Cisplatin
radiation therapy
Radiotherapy
cancer
dosage
Radiation
radiation
tumors
Therapeutics
Squamous Cell Neoplasms
bleeding
Neoplasms
transponders
Spinal Cord Diseases
Radiation Effects
Paresis
infectious diseases
death

Keywords

  • Cisplatin
  • Lung cancer
  • Radiosensitizer
  • Radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Phase II trial of combined radiotherapy and daily low-dose cisplatin for inoperable, locally advanced non-small cell lung cancer (NSCLC). / Harskamp, Gerrit Van; Boven, Epie; Vermorken, Jan B.; Deutekom, Henk Van; Stam, Jaap; Hian Njo, K.; Karim, A. B M F; Tierie, Anton H.; Golding, Richard P.; Pinedo, Herbert M.

In: International Journal of Radiation Oncology, Biology, Physics, Vol. 13, No. 11, 1987, p. 1735-1738.

Research output: Contribution to journalArticle

Harskamp, GV, Boven, E, Vermorken, JB, Deutekom, HV, Stam, J, Hian Njo, K, Karim, ABMF, Tierie, AH, Golding, RP & Pinedo, HM 1987, 'Phase II trial of combined radiotherapy and daily low-dose cisplatin for inoperable, locally advanced non-small cell lung cancer (NSCLC)', International Journal of Radiation Oncology, Biology, Physics, vol. 13, no. 11, pp. 1735-1738. https://doi.org/10.1016/0360-3016(87)90171-4
Harskamp, Gerrit Van ; Boven, Epie ; Vermorken, Jan B. ; Deutekom, Henk Van ; Stam, Jaap ; Hian Njo, K. ; Karim, A. B M F ; Tierie, Anton H. ; Golding, Richard P. ; Pinedo, Herbert M. / Phase II trial of combined radiotherapy and daily low-dose cisplatin for inoperable, locally advanced non-small cell lung cancer (NSCLC). In: International Journal of Radiation Oncology, Biology, Physics. 1987 ; Vol. 13, No. 11. pp. 1735-1738.
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abstract = "With the use of cis-diamminedichloroplatinum(II), cisplatin, to enhance the effect of radiation a combined modality approach was designed to treat patients with inoperable, locally advanced NSCLC. The regimen consisted of radiation doses of 300 cGy for 4 days every week for 4 weeks with a 2 week split in between. Each radiation dose was followed by an i.v. injection of cisplatin 6 mg m2 within 30 min. Hydration consisted on an oral fluid intake of 2 L only, enabling the patient to receive the treatment on an outpatient basis. Of 40 patients entered into the study, 37 were evaluable for toxicity and 33 for response. Overall response rate was 65{\%} and complete response rate 22{\%}. Median duration of local control was 7 months. The majority of all patients (76{\%}) eventually progressed at the primary tumor site, while in 16 patients relapse occurred in distant sites first. Median duration of overall survival was 10.5 months, whereas that of complete responders was 29.5 months. Generally, acute side effects were transient and did not require discontinuation of treatment. One patient presented with thrombocytopenia 4 weeks after treatment had been finished. His death of cerebral bleeding was likely to be related with his therapy-resistant malignancy. Of late side effects three patients showed disabling symptoms consisting of uncontrollable pulmonary infections in the presence of tumor in two patients, one patient had radiation myelopathy and another experienced vertebral collapse with distal paresis. The combination of radiation and daily low-dose cisplatin is a tolerable treatment modality with most benefit for patients reaching a complete remission. Intensification of the regimen is being planned in those patients with inoperable, locally advanced squamous cell lung cancer to reach a complete remission.",
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AU - Boven, Epie

AU - Vermorken, Jan B.

AU - Deutekom, Henk Van

AU - Stam, Jaap

AU - Hian Njo, K.

AU - Karim, A. B M F

AU - Tierie, Anton H.

AU - Golding, Richard P.

AU - Pinedo, Herbert M.

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N2 - With the use of cis-diamminedichloroplatinum(II), cisplatin, to enhance the effect of radiation a combined modality approach was designed to treat patients with inoperable, locally advanced NSCLC. The regimen consisted of radiation doses of 300 cGy for 4 days every week for 4 weeks with a 2 week split in between. Each radiation dose was followed by an i.v. injection of cisplatin 6 mg m2 within 30 min. Hydration consisted on an oral fluid intake of 2 L only, enabling the patient to receive the treatment on an outpatient basis. Of 40 patients entered into the study, 37 were evaluable for toxicity and 33 for response. Overall response rate was 65% and complete response rate 22%. Median duration of local control was 7 months. The majority of all patients (76%) eventually progressed at the primary tumor site, while in 16 patients relapse occurred in distant sites first. Median duration of overall survival was 10.5 months, whereas that of complete responders was 29.5 months. Generally, acute side effects were transient and did not require discontinuation of treatment. One patient presented with thrombocytopenia 4 weeks after treatment had been finished. His death of cerebral bleeding was likely to be related with his therapy-resistant malignancy. Of late side effects three patients showed disabling symptoms consisting of uncontrollable pulmonary infections in the presence of tumor in two patients, one patient had radiation myelopathy and another experienced vertebral collapse with distal paresis. The combination of radiation and daily low-dose cisplatin is a tolerable treatment modality with most benefit for patients reaching a complete remission. Intensification of the regimen is being planned in those patients with inoperable, locally advanced squamous cell lung cancer to reach a complete remission.

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