Phase II trial of CHIP for the treatment of advanced, hormonally refractory carcinoma of the prostate: A Southwest Oncology Group study

M. E. Marshall, M. K. Wolf, E. D. Crawford, G. R. Weiss, F. Ahmann, F. J. Meyers, B. Blumenstein, M. Eisenberger, A. B. Einstein

Research output: Contribution to journalArticle

Abstract

CHIP, a second generation analogue of cisplatin, was subjected to a Phase II trial for the treatment of advanced, hormonally refractory carcinoma of the prostate. Forty-six patients were treated with CHIP 300 mg/m2 intravenously every 4 weeks. Evaluations for tumor response were done after three cycles of therapy. Among 40 evaluable patients there were no complete responses, but there were 6 partial responses for an overall response rate of 15% (95% confidence interval of 5.7 to 29.8%). The median time to response was 2.4 months and the median progression-free survival was 4.1 months. Median survival was 8.4 months. The most common toxicities were hematologic and gastrointestinal. While CHIP can be administered on an outpatient basis, its response rate for prostatic carcinoma appears to be similar to that of cisplatin.

Original languageEnglish (US)
Pages (from-to)400-402
Number of pages3
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume18
Issue number5
DOIs
StatePublished - 1995

Keywords

  • CHIP
  • Prostate cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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