Phase II study of high-dose methotrexate in the treatment of patients with non-small cell carcinoma of the lung

An Eastern Cooperative Oncology Group Study

David S Ettinger, K. E. Stanley, J. S. Nystrom

Research output: Contribution to journalArticle

Abstract

Twenty-eight patients with inoperable non-small cell carcinoma of the lung were treated with high-dose methotrexate with citrovorum factor rescue. One patient (4%) responded with a partial regression of the tumor. Three patients had severe or life-threatening complications: acute renal failure, acute shortness of breath, and bone marrow suppression, respectively. There is 98% confidence that the true response rate for this therapy is

Original languageEnglish (US)
Pages (from-to)1017-1021
Number of pages5
JournalCancer Treatment Reports
Volume64
Issue number10-11
StatePublished - 1980

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Methotrexate
Non-Small Cell Lung Carcinoma
Leucovorin
Acute Kidney Injury
Dyspnea
Therapeutics
Bone Marrow
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Phase II study of high-dose methotrexate in the treatment of patients with non-small cell carcinoma of the lung : An Eastern Cooperative Oncology Group Study. / Ettinger, David S; Stanley, K. E.; Nystrom, J. S.

In: Cancer Treatment Reports, Vol. 64, No. 10-11, 1980, p. 1017-1021.

Research output: Contribution to journalArticle

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