Phase II evaluation of oral estramustine, oral etoposide, and intravenous paclitaxel in patients with hormone-sensitive prostate adenocarcinoma

Niklas J. Mackler, Kenneth J. Pienta, Rodney L. Dunn, Kathleen A. Cooney, Bruce G. Redman, Karin B. Olson, Judith E. Fardig, David C. Smith

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: The primary objective of this study was to assess the feasibility and efficacy of administering etoposide/estramustine/paclitaxel in hormone-sensitive metastatic prostate cancer responding to hormonal therapy. Patients and Methods: Eligible patients had metastatic prostate cancer and had received combined androgen blockade for 6-8 months with a ≥ 80% decrease in prostate-specific antigen from pretreatment. They received 4 cycles of chemotherapy consisting of estramustine 280 mg orally 3 times daily, etoposide 50 mg/m2 orally on days 1-14, and paclitaxel 135 mg/m2 intravenously for 1 hour on day 2 of each 21-day cycle and were then followed until time to treatment failure (TTF). Results: Twenty-six patients were evaluable for response and toxicity. Median TTF was 21.7 months (range, 11.9-64.5 months; 95% confidence interval, 15.3-26.2 months). Median survival from time of initiation of hormone therapy was 5.1 years. Neutropenia was the most common grade 3/4 toxicity, occurring in 3 patients. Significant toxicities were limited to nausea, diarrhea, and febrile neutropenia in 3 patients, respectively. Conclusion: The administration of paclitaxel/estramustine/ etoposide in this setting is feasible and well tolerated. Although the TTF of 21.7 months by prostate-specific antigen criteria is similar to historical controls in the emergence of clinically evident androgen-independent disease after starting hormone therapy, direct comparisons cannot be made. More trials are needed to investigate the timing of chemotherapy in patients with prostate cancer.

Original languageEnglish (US)
Pages (from-to)318-322
Number of pages5
JournalClinical Genitourinary Cancer
Volume5
Issue number5
DOIs
StatePublished - Jun 2007
Externally publishedYes

Keywords

  • Adult medical oncology
  • Chemotherapy
  • Clinical trials

ASJC Scopus subject areas

  • Oncology
  • Urology

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