Phase I trial of valaciclovir, the L-valyl ester of acyclovir, in patients with advanced human immunodeficiency virus disease

M. A. Jacobson, J. Gallant, L. H. Wang, D. Coakley, S. Weller, D. Gary, L. Squires, M. L. Smiley, M. R. Blum, J. Feinberg

Research output: Contribution to journalArticle

Abstract

Valaciclovir, the L-valyl ester of acyclovir, is rapidly and extensively converted in humans to acyclovir after oral administration by first-pass metabolism. A phase I study was conducted in two cohorts of volunteers with advanced human immunodeficiency virus (HIV) disease (absolute CD4 lymphocyte count of

Original languageEnglish (US)
Pages (from-to)1534-1540
Number of pages7
JournalAntimicrobial Agents and Chemotherapy
Volume38
Issue number7
StatePublished - 1994
Externally publishedYes

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valacyclovir
Virus Diseases
HIV
Acyclovir
CD4 Lymphocyte Count
Oral Administration
Volunteers

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Jacobson, M. A., Gallant, J., Wang, L. H., Coakley, D., Weller, S., Gary, D., ... Feinberg, J. (1994). Phase I trial of valaciclovir, the L-valyl ester of acyclovir, in patients with advanced human immunodeficiency virus disease. Antimicrobial Agents and Chemotherapy, 38(7), 1534-1540.

Phase I trial of valaciclovir, the L-valyl ester of acyclovir, in patients with advanced human immunodeficiency virus disease. / Jacobson, M. A.; Gallant, J.; Wang, L. H.; Coakley, D.; Weller, S.; Gary, D.; Squires, L.; Smiley, M. L.; Blum, M. R.; Feinberg, J.

In: Antimicrobial Agents and Chemotherapy, Vol. 38, No. 7, 1994, p. 1534-1540.

Research output: Contribution to journalArticle

Jacobson, MA, Gallant, J, Wang, LH, Coakley, D, Weller, S, Gary, D, Squires, L, Smiley, ML, Blum, MR & Feinberg, J 1994, 'Phase I trial of valaciclovir, the L-valyl ester of acyclovir, in patients with advanced human immunodeficiency virus disease', Antimicrobial Agents and Chemotherapy, vol. 38, no. 7, pp. 1534-1540.
Jacobson, M. A. ; Gallant, J. ; Wang, L. H. ; Coakley, D. ; Weller, S. ; Gary, D. ; Squires, L. ; Smiley, M. L. ; Blum, M. R. ; Feinberg, J. / Phase I trial of valaciclovir, the L-valyl ester of acyclovir, in patients with advanced human immunodeficiency virus disease. In: Antimicrobial Agents and Chemotherapy. 1994 ; Vol. 38, No. 7. pp. 1534-1540.
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