Phase I trial of sorafenib in patients with recurrent or progressive malignant glioma

L. B. Nabors, J. G. Supko, M. Rosenfeld, M. Chamberlain, S. Phuphanich, T. Batchelor, S. Desideri, X. Ye, J. Wright, S. Gujar, S. A. Grossman

Research output: Contribution to journalArticlepeer-review

Abstract

Sorafenib is an inhibitor of multiple kinases that has demonstrated antiproliferative and antiangiogenic activity in a number of in vitro and in vivo model systems. A phase I study was conducted to determine the maximum tolerated dose (MTD) of sorafenib in patients with recurrent malignant glioma. Sorafenib was given orally, twice a day (BID), continuously in 28-day cycles. The dose was escalated in 2 groups of patients stratified by use of enzyme-inducing antiseizure drugs (±EIASDs). Dose-limiting toxicity (DLT) was defined as any grades 3-4 nonhematological toxicity, grade 4 hematological toxicity, and febrile neutropenia. The number of evaluable patients enrolled in the 1EIASD and 2EIASD arms were 23 and 24, respectively. DLTs were predominantly dermatological and gastrointestinal effects, as observed in previous clinical trials of sorafenib. The MTD was 600 mg BID for patients receiving EIASDs and 800 mg BID for those who were not. The plasma pharmacokinetics of sorafenib were not significantly affected by the concurrent administration of EIASDs. The MTD of sorafenib given orally BID on a continuous basis was established as 600 mg BID in patients with malignant glioma who were concurrently receiving EIASDs and 800 mg BID in those who were not. Further evaluation is warranted of sorafenib at the recommended MTD against recurrent or progressive malignant glioma in combination with other molecularly targeted drugs or in the newly diagnosed setting concurrent with chemoradiation.

Original languageEnglish (US)
Pages (from-to)1324-1330
Number of pages7
JournalNeuro-oncology
Volume13
Issue number12
DOIs
StatePublished - Dec 2011
Externally publishedYes

Keywords

  • Angiogenesis
  • Glioma
  • Pharmacokinetics
  • Proliferation
  • Targeted therapy.

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology
  • Cancer Research

Fingerprint Dive into the research topics of 'Phase I trial of sorafenib in patients with recurrent or progressive malignant glioma'. Together they form a unique fingerprint.

Cite this