Phase I trial of intravenous administration of PV701, an oncolytic virus, in patients with advanced solid cancers

Andrew L. Pecora, Naiyer Rizvi, Gary I. Cohen, Neal J. Meropol, Daniel Sterman, John L. Marshall, Stuart Goldberg, Peter Gross, James D. O'Neil, William S. Groene, M. Scot Roberts, Harvey Rabin, Michael K. Bamat, Robert M. Lorence

Research output: Contribution to journalArticle

Abstract

Purpose: PV701, a replication-competent strain of Newcastle disease virus, causes regression of tumor xenografts after intravenous administration. This phase I study was designed to define the maximum-tolerated dose (MTD) and safety of single and multiple intravenous doses of PV701 as a single agent in patients with cancer. Patients and Methods: Seventy-nine patients with advanced solid cancers that were unresponsive to standard therapy were enrolled. Four PV701 intravenous dosing regimens were evaluated: (1) single dose: one dose every 28 days; (2) repeat dose: three doses in 1 week every 28 days; (3) desensitizing: one lower dose followed by two higher doses in 1 week every 28 days; and (4) two week: one lower dose followed by five higher doses over 2 weeks every 21 days. Results: A 100-fold dose intensification was achieved over 195 cycles. A first-dose MTD of 12 × 109 plaque-forming units (PFU)/m2 was established for outpatient dosing. After an initial dose of 12 × 109 PFU/m2, patients tolerated an MTD for subsequent doses of 120 × 109 PFU/m2. The most common adverse events were flu-like symptoms that occurred principally after the first dose and were decreased in number and severity with each subsequent dose. Tumor site-specific adverse events and acute dosing reactions were also observed but not cumulative toxicity. Objective responses occurred at higher dose levels, and progression-free survival ranged from 4 to 31 months. Tumor tissue from one patient was obtained after 11 months of therapy and showed evidence of PV701 particles budding from the tumor cell membrane by electron microscopy and a pronounced lymphoplasmacytic infiltrate by histologic examination. Conclusion: PV701 warrants further study as a novel therapeutic agent for cancer patients.

Original languageEnglish (US)
Pages (from-to)2251-2266
Number of pages16
JournalJournal of Clinical Oncology
Volume20
Issue number9
DOIs
StatePublished - May 1 2002

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Pecora, A. L., Rizvi, N., Cohen, G. I., Meropol, N. J., Sterman, D., Marshall, J. L., Goldberg, S., Gross, P., O'Neil, J. D., Groene, W. S., Roberts, M. S., Rabin, H., Bamat, M. K., & Lorence, R. M. (2002). Phase I trial of intravenous administration of PV701, an oncolytic virus, in patients with advanced solid cancers. Journal of Clinical Oncology, 20(9), 2251-2266. https://doi.org/10.1200/JCO.2002.08.042