Pharmacotherapy for Focal Seizures in Children and Adolescents

Clare E. Stevens, Carl Stafstrom

Research output: Contribution to journalReview articlepeer-review

Abstract

Focal-onset seizures are among the most common forms of seizures in children and adolescents and can be caused by a wide diversity of acquired or genetic etiologies. Despite the increasing array of antiseizure drugs available, treatment of focal-onset seizures in this population remains problematic, with as many as one-third of children having seizures refractory to medications. This review discusses contemporary concepts in focal seizure classification and pathophysiology and describes the antiseizure medications most commonly chosen for this age group. As antiseizure drug efficacy is comparable in children and adults, here we focus on pharmacokinetic aspects, drug–drug interactions, and side effect profiles. Finally, we provide some suggestions for choosing the optimal medication for the appropriate patient.

Original languageEnglish (US)
Pages (from-to)1321-1337
Number of pages17
JournalDrugs
Volume78
Issue number13
DOIs
StatePublished - Sep 1 2018

ASJC Scopus subject areas

  • Pharmacology (medical)

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