Pharmacomechanical thrombolysis of experimental pulmonary emboli: Rapid low-dose intraembolic therapy

V. F. Tapson, P. A. Gurbel, L. A. Witty, K. S. Pieper, R. S. Stack

Research output: Contribution to journalArticle

Abstract

We utilized low-dose intraembolic urokinase (UK) infusions in a canine model of experimental pulmonary embolism (PE) and compared the arteriographic extent of thrombolysis with three other treatment regimens. Group 1 animals (n=16) received the intraembolic UK infused directly into the PE offering the mechanical effect of the infusion combined with pharmacologic thrombolysis. In the group 2 animals (n=5), UK was delivered via a guide catheter placed proximal to the clot. Group 3 animals (n=6) were treated with a direct intraembolic saline solution infusion. Group 4 (n=7) received only intravenous heparin. The arteriographic extent of thrombolysis was graded 1+ to 3+. The extent of thrombolysis was 2.88+ in the group 1 animals and was significantly greater than in groups 2, 3, or 4 (p=0.003, 0.0005, and 0.0001, respectively). Fibrinogen levels did not significantly decrease with intraembolic treatment (p=0.07). Delivery of UK directly into emboli in an experimental canine PE model appears to elicit a combined mechanical and pharmacologic effect resulting in extensive thrombolysis.

Original languageEnglish (US)
Pages (from-to)1558-1562
Number of pages5
JournalChest
Volume106
Issue number5
StatePublished - 1994
Externally publishedYes

Fingerprint

Urokinase-Type Plasminogen Activator
Embolism
Pulmonary Embolism
Lung
Canidae
Therapeutics
Sodium Chloride
Fibrinogen
Heparin
Theoretical Models
Catheters

Keywords

  • fibrinogenolysis
  • pulmonary embolism
  • thrombolytic therapy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Tapson, V. F., Gurbel, P. A., Witty, L. A., Pieper, K. S., & Stack, R. S. (1994). Pharmacomechanical thrombolysis of experimental pulmonary emboli: Rapid low-dose intraembolic therapy. Chest, 106(5), 1558-1562.

Pharmacomechanical thrombolysis of experimental pulmonary emboli : Rapid low-dose intraembolic therapy. / Tapson, V. F.; Gurbel, P. A.; Witty, L. A.; Pieper, K. S.; Stack, R. S.

In: Chest, Vol. 106, No. 5, 1994, p. 1558-1562.

Research output: Contribution to journalArticle

Tapson, VF, Gurbel, PA, Witty, LA, Pieper, KS & Stack, RS 1994, 'Pharmacomechanical thrombolysis of experimental pulmonary emboli: Rapid low-dose intraembolic therapy', Chest, vol. 106, no. 5, pp. 1558-1562.
Tapson VF, Gurbel PA, Witty LA, Pieper KS, Stack RS. Pharmacomechanical thrombolysis of experimental pulmonary emboli: Rapid low-dose intraembolic therapy. Chest. 1994;106(5):1558-1562.
Tapson, V. F. ; Gurbel, P. A. ; Witty, L. A. ; Pieper, K. S. ; Stack, R. S. / Pharmacomechanical thrombolysis of experimental pulmonary emboli : Rapid low-dose intraembolic therapy. In: Chest. 1994 ; Vol. 106, No. 5. pp. 1558-1562.
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