Pharmacology of vagal afferent nerve activity in guinea pig airways

Michael J. Carr, Bradley J. Undem

Research output: Contribution to journalArticlepeer-review

Abstract

The excitability and activity of vagal afferent nerves innervating the airways can be pharmacologically increased and decreased. Autacoids released as a result of airway inflammation can lead to substantial increases in afferent nerve activity, consequently altering pulmonary reflex physiology. In a manner analogous to hyperalgesia associated with inflammation in the somato-sensory system, increases in vagal afferent nerve activity in inflamed airways may lead to a heightened cough reflex, and increases in autonomic activity in the airways. These effects may contribute to many of the symptoms of inflammatory airway disease. Here we provide a brief overview of some of the mechanisms by which the afferent activity in airway nerves can be pharmacologically modified.

Original languageEnglish (US)
Pages (from-to)45-52
Number of pages8
JournalPulmonary Pharmacology and Therapeutics
Volume16
Issue number1
DOIs
StatePublished - Feb 2003

Keywords

  • Capsaicin
  • Guinea pig
  • Vagal afferent nerve

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Biochemistry, medical
  • Pharmacology (medical)

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