Pharmacology of trimethoprim-sulfamethoxazole in newborn infants

Paul S. Lietman, Chaim Springer, Fabian Eyal, Jacques Michel

Research output: Contribution to journalArticlepeer-review

Abstract

The pharmacokinetic parameters of sulfamethoxazole and trimethoprim were measured in 12 newborn infants of less than 3 days postnatal age, following a single or repeated intravenous injection. The mean half-lives for SMZ and TMP were 16.5 hours and 19.0 hours, respectively. The mean volumes of distribution were SMZ 0.48 L/kg and TMP 2.7 L/kg. The mean drug clearances were SMZ 0.65 ml/minute and TMP 3.31 ml/minute. From these data the recommended loading dose is SMZ 10 mg/kg with TMP 3 mg/kg, and the maintenance dose is SMZ 3 mg/kg with TMP 1 mg/kg twice daily. No adverse side effects were seen during treatment, and the bilirubin-binding capacity of albumin was not changed at therapeutic concentrations of the antimicrobial drugs.

Original languageEnglish (US)
Pages (from-to)647-650
Number of pages4
JournalThe Journal of pediatrics
Volume100
Issue number4
DOIs
StatePublished - Apr 1982

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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