Pharmacology of nasal provocation with bradykinin: Studies of tachyphylaxis, cyclooxygenase inhibition, α-adrenergic stimulation, and receptor subtype

Laurie Churchill, Jacqueline A. Pongracic, Curt J. Reynolds, Robert M. Naclerio, David Proud

Research output: Contribution to journalArticle

Abstract

We have evaluated mechanisms by which nasal provocation with bradykinin may induce symptoms of rhinitis. Repeated nasal challenges with 100 µg of bradykinin led to reproducible increases in symptoms and in vascular permeability. Premedication with aspirin did not alter bradykinin-induced responses. Topical application of the α-adrenergic agonist oxymetazoline significantly reduced bradykinin-induced subjective nasal congestion scores, but did not lead to a significant decrease in total symptoms or in vascular permeability. Finally, the B1 kinin receptor agonist des-Arg9-bradykinin (1 mg) was totally ineffective in inducing symptoms or increasing vascular permeability. Thus, nasal provocation with bradykinin leads to induction of symptoms and increased vascular permeability, presumably via stimulation of B2 kinin receptors, and is not dependent on prostanoid generation.

Original languageEnglish (US)
Pages (from-to)322-331
Number of pages10
JournalInternational Archives of Allergy and Immunology
Volume95
Issue number4
DOIs
StatePublished - 1991

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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