TY - JOUR
T1 - Pharmacology and use of muscle relaxants in infants and children
AU - Nugent, Stephen K.
AU - Larvuso, Raymond
AU - Rogers, Mark C.
PY - 1979/3
Y1 - 1979/3
N2 - Succinylcholine is a short-acting depolarizing neuromuscular blocker used to facilitate intubation; pancuronium is a longer-acting, nondepolarizing agent commonly employed to control ventilation in pediatic patients. The neuromuscular block produced by both drugs may be modified by patient age, acid-base and electrolyte status, body temperature, and drugs such as aminoglycoside antibiotics; adjustment in dose or in technique of administration may be required. Cardiovascular side-effects, primarily arrhythmias, are occasionally associated with the use of either agent. In contrast to that of succinylcholine, the paralysis from pancuronium is pharmacologically reversible with the combination of atropine and neostigmine.
AB - Succinylcholine is a short-acting depolarizing neuromuscular blocker used to facilitate intubation; pancuronium is a longer-acting, nondepolarizing agent commonly employed to control ventilation in pediatic patients. The neuromuscular block produced by both drugs may be modified by patient age, acid-base and electrolyte status, body temperature, and drugs such as aminoglycoside antibiotics; adjustment in dose or in technique of administration may be required. Cardiovascular side-effects, primarily arrhythmias, are occasionally associated with the use of either agent. In contrast to that of succinylcholine, the paralysis from pancuronium is pharmacologically reversible with the combination of atropine and neostigmine.
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U2 - 10.1016/S0022-3476(79)80608-3
DO - 10.1016/S0022-3476(79)80608-3
M3 - Article
C2 - 423041
AN - SCOPUS:0018425219
SN - 0022-3476
VL - 94
SP - 481
EP - 487
JO - The Journal of pediatrics
JF - The Journal of pediatrics
IS - 3
ER -