Pharmacology and use of muscle relaxants in infants and children

Stephen K. Nugent, Raymond Larvuso, Mark C. Rogers

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Succinylcholine is a short-acting depolarizing neuromuscular blocker used to facilitate intubation; pancuronium is a longer-acting, nondepolarizing agent commonly employed to control ventilation in pediatic patients. The neuromuscular block produced by both drugs may be modified by patient age, acid-base and electrolyte status, body temperature, and drugs such as aminoglycoside antibiotics; adjustment in dose or in technique of administration may be required. Cardiovascular side-effects, primarily arrhythmias, are occasionally associated with the use of either agent. In contrast to that of succinylcholine, the paralysis from pancuronium is pharmacologically reversible with the combination of atropine and neostigmine.

Original languageEnglish (US)
Pages (from-to)481-487
Number of pages7
JournalThe Journal of pediatrics
Issue number3
StatePublished - Mar 1979

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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