Pharmacology and use of muscle relaxants in infants and children

Stephen K. Nugent, Raymond Larvuso, Mark C. Rogers

Research output: Contribution to journalArticle

Abstract

Succinylcholine is a short-acting depolarizing neuromuscular blocker used to facilitate intubation; pancuronium is a longer-acting, nondepolarizing agent commonly employed to control ventilation in pediatic patients. The neuromuscular block produced by both drugs may be modified by patient age, acid-base and electrolyte status, body temperature, and drugs such as aminoglycoside antibiotics; adjustment in dose or in technique of administration may be required. Cardiovascular side-effects, primarily arrhythmias, are occasionally associated with the use of either agent. In contrast to that of succinylcholine, the paralysis from pancuronium is pharmacologically reversible with the combination of atropine and neostigmine.

Original languageEnglish (US)
Pages (from-to)481-487
Number of pages7
JournalJournal of Pediatrics
Volume94
Issue number3
DOIs
StatePublished - 1979

Fingerprint

Pancuronium
Succinylcholine
Neuromuscular Depolarizing Agents
Pharmacology
Neuromuscular Blocking Agents
Neostigmine
Muscles
Neuromuscular Blockade
Aminoglycosides
Body Temperature
Atropine
Intubation
Paralysis
Pharmaceutical Preparations
Electrolytes
Ventilation
Cardiac Arrhythmias
Anti-Bacterial Agents
Acids

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Pharmacology and use of muscle relaxants in infants and children. / Nugent, Stephen K.; Larvuso, Raymond; Rogers, Mark C.

In: Journal of Pediatrics, Vol. 94, No. 3, 1979, p. 481-487.

Research output: Contribution to journalArticle

Nugent, Stephen K. ; Larvuso, Raymond ; Rogers, Mark C. / Pharmacology and use of muscle relaxants in infants and children. In: Journal of Pediatrics. 1979 ; Vol. 94, No. 3. pp. 481-487.
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