Pharmacological therapy for acute spinal cord injury

R. John Hurlbert, Mark N. Hadley, Beverly C. Walters, Bizhan Aarabi, Sanjay S. Dhall, Daniel E. Gelb, Curtis J. Rozzelle, Timothy C. Ryken, Nicholas Theodore

Research output: Contribution to journalArticle

Abstract

Despite 4 prospective blinded randomized controlled trials investigating the effect of MP in acute SCI, there exists no Class I medical evidence of any beneficial effect.2,4,8,20 Two prospective Class II trials also failed to demonstrate the therapeutic efficacy of MP in SCI.14,29 In total, over 980 patients have received steroids for SCI and over 280 have participated as control subjects within the protocol of a prospective clinical trial-in which, universally, all primary comparisons to establish efficacy have been negative. A variety of Class III medical evidence has been published supporting the neuroprotective effect ofMPin SCI.

Original languageEnglish (US)
Pages (from-to)93-105
Number of pages13
JournalNeurosurgery
Volume72
Issue numberSUPPL.2
DOIs
StatePublished - Mar 1 2013

Keywords

  • GM-1 ganglioside
  • Mehtylprednisolone
  • NASCIS trials
  • Pharmacologic therapy
  • Sygen trials

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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  • Cite this

    Hurlbert, R. J., Hadley, M. N., Walters, B. C., Aarabi, B., Dhall, S. S., Gelb, D. E., Rozzelle, C. J., Ryken, T. C., & Theodore, N. (2013). Pharmacological therapy for acute spinal cord injury. Neurosurgery, 72(SUPPL.2), 93-105. https://doi.org/10.1227/NEU.0b013e31827765c6