Pharmacological Strategies to Retard Cardiovascular Aging

Irene Alfaras, Clara Di Germanio, Michel Bernier, Anna Csiszar, Zoltan Ungvari, Edward G. Lakatta, Rafael De Cabo

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations

Abstract

Aging is the major risk factor for cardiovascular diseases, which are the leading cause of death in the United States. Traditionally, the effort to prevent cardiovascular disease has been focused on addressing the conventional risk factors, including hypertension, hyperglycemia, hypercholesterolemia, and high circulating levels of triglycerides. However, recent preclinical studies have identified new approaches to combat cardiovascular disease. Calorie restriction has been reproducibly shown to prolong lifespan in various experimental model animals. This has led to the development of calorie restriction mimetics and other pharmacological interventions capable to delay age-related diseases. In this review, we will address the mechanistic effects of aging per se on the cardiovascular system and focus on the prolongevity benefits of various therapeutic strategies that support cardiovascular health.

Original languageEnglish (US)
Pages (from-to)1626-1642
Number of pages17
JournalCirculation research
Volume118
Issue number10
DOIs
StatePublished - May 13 2016
Externally publishedYes

Keywords

  • aging
  • calorie restriction
  • cardiovascular diseases
  • pharmacological strategies
  • prevention

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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