@article{3f8ec26dd91641e9b802ec81748b5b96,
title = "Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of Fragile X syndrome",
abstract = "Fragile X syndrome is a leading heritable cause of mental retardation that results from the loss of FMR1 gene function. A Drosophila model for Fragile X syndrome, based on the loss of dfmr1 activity, exhibits phenotypes that bear similarity to Fragile X-related symptoms. Herein, we demonstrate that treatment with metabotropic glutamate receptor (mGluR) antagonists or lithium can rescue courtship and mushroom body defects observed in these flies. Furthermore, we demonstrate that dfmr1 mutants display cognitive deficits in experience-dependent modification of courtship behavior, and treatment with mGluR antagonists or lithium restores these memory defects. These findings implicate enhanced mGluR signaling as the underlying cause of the cognitive, as well as some of the behavioral and neuronal, phenotypes observed in the Drosophila Fragile X model. They also raise the possibility that compounds having similar effects on metabotropic glutamate receptors may ameliorate cognitive and behavioral defects observed in Fragile X patients.",
author = "McBride, {Sean M.J.} and Choi, {Catherine H.} and Yan Wang and David Liebelt and Evan Braunstein and David Ferreiro and Amita Sehgal and Siwicki, {Kathleen K.} and Dockendorff, {Thomas C.} and Nguyen, {Hanh T.} and McDonald, {Thomas V.} and Jongens, {Thomas A.}",
note = "Funding Information: Thanks to J.B. Jenkins, J. Hinchey, and S. Campbell for critical reading of the manuscript and scientific discussion. Thanks to R.J. Hagerman, L.C. Griffith, and M. Tranfaglia for helpful comments in addressing specific aspects of the manuscript. Thanks to L. Restifo for discussing results prior to publication and for helpful tips for the analysis of mushroom body morphology. Thanks to R.C. McBride, G.M. McBride, P.J. McBride, R.J. Choi, E. Carlin, S. Chiorean, R. Rudominer, and B. Schoenfeld for technical assistance. We thank the FRAXA Research Foundation for support of Y. Wang and partial support of S. Chiorean, as well as the gift of MPEP. This work was also supported in part by an NIH grant to T.A.J. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",
year = "2005",
month = mar,
day = "3",
doi = "10.1016/j.neuron.2005.01.038",
language = "English (US)",
volume = "45",
pages = "753--764",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "5",
}