TY - JOUR
T1 - Pharmacological management of the psychiatric aspects of traumatic brain injury
AU - Lee, Hochang B.
AU - Lyketsos, Constantine G.
AU - Rao, Vani
N1 - Funding Information:
This paper was partially supported by NIMH grant #T32-14592.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2003/11
Y1 - 2003/11
N2 - Traumatic brain injury (TBI) is a significant public health problem that affects millions of people annually in the USA. Neuropsychiatric symptoms such as cognitive deficits, depression, mania, anxiety, psychosis, apathy, and sleep disturbance are common after TBI. An extensive array of pharmacological options are available to treat a wide range of neuropsychiatric sequelae of TBI, yet there have been few controlled clinical trials to assess the effects of pharmacotherapy in TBI patients. Treatment of the neuropsychiatric disturbances associated with TBI should result in decreased handicap, improved quality of life, and decreased societal impact. There is a dire need for large, randomized, double blind, placebo-controlled trials that include a broad range of cognitive and behavioral outcome measures.
AB - Traumatic brain injury (TBI) is a significant public health problem that affects millions of people annually in the USA. Neuropsychiatric symptoms such as cognitive deficits, depression, mania, anxiety, psychosis, apathy, and sleep disturbance are common after TBI. An extensive array of pharmacological options are available to treat a wide range of neuropsychiatric sequelae of TBI, yet there have been few controlled clinical trials to assess the effects of pharmacotherapy in TBI patients. Treatment of the neuropsychiatric disturbances associated with TBI should result in decreased handicap, improved quality of life, and decreased societal impact. There is a dire need for large, randomized, double blind, placebo-controlled trials that include a broad range of cognitive and behavioral outcome measures.
UR - http://www.scopus.com/inward/record.url?scp=0242659426&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0242659426&partnerID=8YFLogxK
U2 - 10.1080/09540260310001606746
DO - 10.1080/09540260310001606746
M3 - Review article
C2 - 15276957
AN - SCOPUS:0242659426
SN - 0954-0261
VL - 15
SP - 359
EP - 370
JO - International Review of Psychiatry
JF - International Review of Psychiatry
IS - 4
ER -