Pharmacological comparison of two different insect models using the scorpion α-like toxin BmK M1 from Buthus martensii karsch

Frank Bosmans; Bert Brône; Yan Mei Sun; Rong Huan Zhu; Yu Mei Xiong; Da Cheng Wang; Emmy Van Kerkhove; Jan Tytgat

doi:10.2174/0929866053765635

Pharmacological comparison of two different insect models using the scorpion α-like toxin BmK M1 from Buthus martensii karsch

Frank Bosmans, Bert Brône, Yan Mei Sun, Rong Huan Zhu, Yu Mei Xiong, Da Cheng Wang, Emmy Van Kerkhove, Jan Tytgat

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

In this study, the effect of the scorpion α-like toxin BmK M1 was investigated on isolated DUM neurons from Locusta migratoria and compared with the effect on para/tipE voltage-gated Na⁺ channels (VGSC), cloned from Drosophila melanogaster. The two insects display different pharmacological properties regarding α-like toxins. Moreover, with the aid of the α-like toxin BmK M1 and 5 of its mutants, the importance of aromatic residues for the interaction of the toxin with the VGSC in L. migratoria and D. melanogaster, is shown.

Original language	English (US)
Pages (from-to)	363-367
Number of pages	5
Journal	Protein and Peptide Letters
Volume	12
Issue number	4
DOIs	https://doi.org/10.2174/0929866053765635
State	Published - May 2005
Externally published	Yes

Keywords

BmKM1
Locust DUM neurons
Para/tipE
Voltage-gated Na channels

ASJC Scopus subject areas

Structural Biology
Biochemistry

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10.2174/0929866053765635

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title = "Pharmacological comparison of two different insect models using the scorpion α-like toxin BmK M1 from Buthus martensii karsch",

abstract = "In this study, the effect of the scorpion α-like toxin BmK M1 was investigated on isolated DUM neurons from Locusta migratoria and compared with the effect on para/tipE voltage-gated Na+ channels (VGSC), cloned from Drosophila melanogaster. The two insects display different pharmacological properties regarding α-like toxins. Moreover, with the aid of the α-like toxin BmK M1 and 5 of its mutants, the importance of aromatic residues for the interaction of the toxin with the VGSC in L. migratoria and D. melanogaster, is shown.",

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T1 - Pharmacological comparison of two different insect models using the scorpion α-like toxin BmK M1 from Buthus martensii karsch

AU - Bosmans, Frank

AU - Brône, Bert

AU - Sun, Yan Mei

AU - Zhu, Rong Huan

AU - Xiong, Yu Mei

AU - Wang, Da Cheng

AU - Van Kerkhove, Emmy

AU - Tytgat, Jan

PY - 2005/5

Y1 - 2005/5

N2 - In this study, the effect of the scorpion α-like toxin BmK M1 was investigated on isolated DUM neurons from Locusta migratoria and compared with the effect on para/tipE voltage-gated Na+ channels (VGSC), cloned from Drosophila melanogaster. The two insects display different pharmacological properties regarding α-like toxins. Moreover, with the aid of the α-like toxin BmK M1 and 5 of its mutants, the importance of aromatic residues for the interaction of the toxin with the VGSC in L. migratoria and D. melanogaster, is shown.

AB - In this study, the effect of the scorpion α-like toxin BmK M1 was investigated on isolated DUM neurons from Locusta migratoria and compared with the effect on para/tipE voltage-gated Na+ channels (VGSC), cloned from Drosophila melanogaster. The two insects display different pharmacological properties regarding α-like toxins. Moreover, with the aid of the α-like toxin BmK M1 and 5 of its mutants, the importance of aromatic residues for the interaction of the toxin with the VGSC in L. migratoria and D. melanogaster, is shown.

KW - BmKM1

KW - Locust DUM neurons

KW - Para/tipE

KW - Voltage-gated Na channels

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Pharmacological comparison of two different insect models using the scorpion α-like toxin BmK M1 from Buthus martensii karsch

Abstract

Keywords

ASJC Scopus subject areas

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