Pharmacological comparison of two different insect models using the scorpion α-like toxin BmK M1 from Buthus martensii karsch

Frank Bosmans, Bert Brône, Yan Mei Sun, Rong Huan Zhu, Yu Mei Xiong, Da Cheng Wang, Emmy Van Kerkhove, Jan Tytgat

Research output: Contribution to journalArticlepeer-review

Abstract

In this study, the effect of the scorpion α-like toxin BmK M1 was investigated on isolated DUM neurons from Locusta migratoria and compared with the effect on para/tipE voltage-gated Na+ channels (VGSC), cloned from Drosophila melanogaster. The two insects display different pharmacological properties regarding α-like toxins. Moreover, with the aid of the α-like toxin BmK M1 and 5 of its mutants, the importance of aromatic residues for the interaction of the toxin with the VGSC in L. migratoria and D. melanogaster, is shown.

Original languageEnglish (US)
Pages (from-to)363-367
Number of pages5
JournalProtein and Peptide Letters
Volume12
Issue number4
DOIs
StatePublished - May 2005

Keywords

  • BmKM1
  • Locust DUM neurons
  • Para/tipE
  • Voltage-gated Na channels

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry

Fingerprint

Dive into the research topics of 'Pharmacological comparison of two different insect models using the scorpion α-like toxin BmK M1 from Buthus martensii karsch'. Together they form a unique fingerprint.

Cite this