@article{d101f791c3e446b2b1b951ec82c2bf81,
title = "Pharmacologic and toxicologic evaluation of C. novyi-NT spores",
abstract = "Clostridium novyi-NT (C. novyi-NT) spores have been shown to be potent therapeutic agents in experimental tumors of mice and rabbits. In the present study, pharmacologic and toxicologic studies were performed to better understand the factors influencing the efficacy and toxicity of this form of therapy. We found that spores were rapidly cleared from the circulation by the reticuloendothelial system. Even after large doses were administered, no clinical toxicity was observed in healthy mice or rabbits. The spores were also not toxic in mice harboring poorly vascularized non-neoplastic lesions, including myocardial infarcts. In tumor-bearing mice, toxicity appeared related to tumor size and spore dose, as expected with any bacterial infection. However, there was no laboratory or histopathologic evidence of sepsis, and the toxicity could be effectively controlled by simple hydration.",
author = "Diaz, {Luis A.} and Ian Cheong and Foss, {Catherine A.} and Xiaosong Zhang and Peters, {Brock A.} and Nishant Agrawal and Chetan Bettegowda and Baktiar Karim and Guosheng Liu and Khalid Khan and Xin Huang and Manu Kohli and Dang, {Long H.} and Paul Hwang and Ahava Vogelstein and Elizabeth Garrett-Mayer and Barry Kobrin and Martin Pomper and Shibin Zhou and Kinzler, {Kenneth W.} and Bert Vogelstein and Huso, {David L.}",
note = "Funding Information: The authors thank Lattice Watson for excellent technical assistance and Harriet Chapman and the staff of the Cancer Research Building (CRB) animal facilities of the Sidney Kimmel Cancer Center for assistance with animal experiments. We thank Satoaki Matoba and Willmar Patino for providing atherosclerosis model mice and San Hong for cardiac infarction surgery. This work was supported by the Miracle Foundation, the Clayton Fund, and National Institutes of Health grants RR00171, CA062924, CA43460, CA92871, and CA103175.",
year = "2005",
month = dec,
doi = "10.1093/toxsci/kfi316",
language = "English (US)",
volume = "88",
pages = "562--575",
journal = "Toxicological Sciences",
issn = "1096-6080",
publisher = "Oxford University Press",
number = "2",
}