TY - JOUR
T1 - Pharmacologic advances in the global control and treatment of malaria
T2 - Combination therapy and resistance
AU - Nyunt, M. M.
AU - Plowe, C. V.
PY - 2007/11
Y1 - 2007/11
N2 - Combination drug therapy for malaria is recommended both to prevent and to overcome drug resistance. Drug combinations developed for use in Asia are being deployed in Africa, where higher rates of malaria affect the therapeutic and public health objectives of malaria chemotherapy as well as drug safety. Rational consideration of drug mechanisms, pharmacokinetics (PK), pharmacodynamics (PD), and malaria epidemiology should result in more effective combination regimens that retain therapeutic and prophylactic efficacy in the face of resistance.
AB - Combination drug therapy for malaria is recommended both to prevent and to overcome drug resistance. Drug combinations developed for use in Asia are being deployed in Africa, where higher rates of malaria affect the therapeutic and public health objectives of malaria chemotherapy as well as drug safety. Rational consideration of drug mechanisms, pharmacokinetics (PK), pharmacodynamics (PD), and malaria epidemiology should result in more effective combination regimens that retain therapeutic and prophylactic efficacy in the face of resistance.
UR - http://www.scopus.com/inward/record.url?scp=35448959339&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35448959339&partnerID=8YFLogxK
U2 - 10.1038/sj.clpt.6100361
DO - 10.1038/sj.clpt.6100361
M3 - Article
C2 - 17898709
AN - SCOPUS:35448959339
SN - 0009-9236
VL - 82
SP - 601
EP - 605
JO - Clinical Pharmacology and Therapeutics
JF - Clinical Pharmacology and Therapeutics
IS - 5
ER -