Pharmacologic activities of copper compounds in chronic diseases

John R.J. Sorenson, Larry W. Oberley, Rosalie K. Crouch, Thomas W. Kensler, Vimal Kishore, Susan W.C. Leuthauser, Terry D. Oberley, Abbas Pezeshk

Research output: Contribution to journalArticlepeer-review

Abstract

Copper complexes have been shown to be effective antiinflammatory, antiulcer, anticonvulsant, anticancer, and antidiabetic agents. This seemingly diverse variety of pharmacologic effects is unified by the hypothesis that copper complexes facilitate or promote tissue repair processes involving copper-dependent enzymes and that arthritis, ulcers, seizures, neoplasia, and diabetes are diseases of specific tissues in disrepair. The corollary to this hypothesis is that the loss or reduction of copper-dependent enzyme-mediated processes leads to tissue dysfunction that may be reversed with copper complex therapy.

Original languageEnglish (US)
Pages (from-to)257-273
Number of pages17
JournalBiological Trace Element Research
Volume5
Issue number4-5
DOIs
StatePublished - Aug 1 1983

Keywords

  • Copper complexes, antiinflammatory activity of
  • anticancer agents, copper complexes as
  • anticonvulsants, copper complexes as
  • antidiabetic agents, copper complexes as
  • antiulcer agents, copper complexes as
  • copper-dependent enzymes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical
  • Inorganic Chemistry

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