Pharmacokinetics of Polymeric Drug Delivery

Many aspects of polymeric drug delivery have been investigated over the past three decades, and pharmacokinetic and pharmacodynamic models have been developed to enhance our understanding of properties such as polymer degradation and elimination from the body, biocompatibility with the brain parenchyma, and the occurrence of toxicities. Extensive studies in animal models and in patients have also provided ample evidence for the biocompatibility and biodegradability of the polymeric matrix in the area surrounding the implantation site. In this chapter, we review the innate physical barriers of the central nervous system that necessitated local delivery of therapeutics, and review the modeling that helps predict compound distribution and dissolution within the intracranial space.