Pharmacokinetics of oral zidovudine entrapped in biodegradable nanospheres in rabbits

Diana P. Callender; Nalini Jayaprakash; Aaron Bell; Vidmantas Petraitis; Ruta Petratienes; Myrna Candelario; Robert Schaufele; James M. Dunn; Shizuko Sei; Thomas J. Walsh; Frank M. Balis

doi:10.1128/aac.43.4.972

Pharmacokinetics of oral zidovudine entrapped in biodegradable nanospheres in rabbits

Diana P. Callender, Nalini Jayaprakash, Aaron Bell, Vidmantas Petraitis, Ruta Petratienes, Myrna Candelario, Robert Schaufele, James M. Dunn, Shizuko Sei, Thomas J. Walsh, Frank M. Balis

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The pharmacokinetic profile of oral zidovudine entrapped in a 50:50 polyactide-coglycolide matrix (nanospheres) was compared to those of standard oral and parenteral zidovudine formulations in rabbits. The bioavailability of zidovudine nanospheres at 50 mg/kg of body weight was 76%, and this dose achieved prolonged exposure to zidovudine compared to standard formulations without an increase in the drug's peak concentration.

Original language	English (US)
Pages (from-to)	972-974
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	43
Issue number	4
DOIs	https://doi.org/10.1128/aac.43.4.972
State	Published - Apr 1999
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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title = "Pharmacokinetics of oral zidovudine entrapped in biodegradable nanospheres in rabbits",

abstract = "The pharmacokinetic profile of oral zidovudine entrapped in a 50:50 polyactide-coglycolide matrix (nanospheres) was compared to those of standard oral and parenteral zidovudine formulations in rabbits. The bioavailability of zidovudine nanospheres at 50 mg/kg of body weight was 76%, and this dose achieved prolonged exposure to zidovudine compared to standard formulations without an increase in the drug's peak concentration.",

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AU - Callender, Diana P.

AU - Jayaprakash, Nalini

AU - Bell, Aaron

AU - Petraitis, Vidmantas

AU - Petratienes, Ruta

AU - Candelario, Myrna

AU - Schaufele, Robert

AU - Dunn, James M.

AU - Sei, Shizuko

AU - Walsh, Thomas J.

AU - Balis, Frank M.

PY - 1999/4

Y1 - 1999/4

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AB - The pharmacokinetic profile of oral zidovudine entrapped in a 50:50 polyactide-coglycolide matrix (nanospheres) was compared to those of standard oral and parenteral zidovudine formulations in rabbits. The bioavailability of zidovudine nanospheres at 50 mg/kg of body weight was 76%, and this dose achieved prolonged exposure to zidovudine compared to standard formulations without an increase in the drug's peak concentration.

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Pharmacokinetics of oral zidovudine entrapped in biodegradable nanospheres in rabbits

Abstract

ASJC Scopus subject areas

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