Pharmacokinetics of oral zidovudine entrapped in biodegradable nanospheres in rabbits

Diana P. Callender, Nalini Jayaprakash, Aaron Bell, Vidmantas Petraitis, Ruta Petratienes, Myrna Candelario, Robert Schaufele, James M. Dunn, Shizuko Sei, Thomas J. Walsh, Frank M. Balis

Research output: Contribution to journalArticlepeer-review

Abstract

The pharmacokinetic profile of oral zidovudine entrapped in a 50:50 polyactide-coglycolide matrix (nanospheres) was compared to those of standard oral and parenteral zidovudine formulations in rabbits. The bioavailability of zidovudine nanospheres at 50 mg/kg of body weight was 76%, and this dose achieved prolonged exposure to zidovudine compared to standard formulations without an increase in the drug's peak concentration.

Original languageEnglish (US)
Pages (from-to)972-974
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume43
Issue number4
DOIs
StatePublished - Apr 1999

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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