Pharmacokinetics of liposomal amphotericin B in pleural fluid

Brad Moriyama, Parizad Torabi-Parizi, Alexandra K. Pratt, Stacey A. Henning, Gennethel Pennick, Yvonne R. Shea, Sinchita Roy Chowdhuri, Michael G. Rinaldi, A. John Barrett, Thomas J. Walsh

Research output: Contribution to journalArticlepeer-review

Abstract

We report the penetration of liposomal amphotericin B into the pleural fluid of a patient with pulmonary zygomycosis and empyema. The ratio of area under the concentration-versus-time curve in pleural fluid (AUC pleural fluid) to that in serum (AUCserum) for liposomal amphotericin B over 24 h was 9.4%, with pleural fluid concentrations of 2.12 to 4.91 μg/ml. Given the relatively low level of intrapleural penetration of liposomal amphotericin B, chest tube drainage may be warranted for successful treatment of zygomycotic empyema.

Original languageEnglish (US)
Pages (from-to)1633-1635
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume54
Issue number4
DOIs
StatePublished - Apr 2010

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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