Pharmacokinetics of liposomal amphotericin B in pleural fluid

Brad Moriyama, Parizad Torabi-Parizi, Alexandra K. Pratt, Stacey A. Henning, Gennethel Pennick, Yvonne R. Shea, Sinchita Roy Chowdhuri, Michael G. Rinaldi, A. John Barrett, Thomas J. Walsh

Research output: Contribution to journalArticle

Abstract

We report the penetration of liposomal amphotericin B into the pleural fluid of a patient with pulmonary zygomycosis and empyema. The ratio of area under the concentration-versus-time curve in pleural fluid (AUC pleural fluid) to that in serum (AUCserum) for liposomal amphotericin B over 24 h was 9.4%, with pleural fluid concentrations of 2.12 to 4.91 μg/ml. Given the relatively low level of intrapleural penetration of liposomal amphotericin B, chest tube drainage may be warranted for successful treatment of zygomycotic empyema.

Original languageEnglish (US)
Pages (from-to)1633-1635
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume54
Issue number4
DOIs
StatePublished - Apr 2010
Externally publishedYes

Fingerprint

Empyema
Pharmacokinetics
Zygomycosis
Chest Tubes
Drainage
Lung
Serum
liposomal amphotericin B
Therapeutics

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

Moriyama, B., Torabi-Parizi, P., Pratt, A. K., Henning, S. A., Pennick, G., Shea, Y. R., ... Walsh, T. J. (2010). Pharmacokinetics of liposomal amphotericin B in pleural fluid. Antimicrobial Agents and Chemotherapy, 54(4), 1633-1635. https://doi.org/10.1128/AAC.01438-09

Pharmacokinetics of liposomal amphotericin B in pleural fluid. / Moriyama, Brad; Torabi-Parizi, Parizad; Pratt, Alexandra K.; Henning, Stacey A.; Pennick, Gennethel; Shea, Yvonne R.; Chowdhuri, Sinchita Roy; Rinaldi, Michael G.; Barrett, A. John; Walsh, Thomas J.

In: Antimicrobial Agents and Chemotherapy, Vol. 54, No. 4, 04.2010, p. 1633-1635.

Research output: Contribution to journalArticle

Moriyama, B, Torabi-Parizi, P, Pratt, AK, Henning, SA, Pennick, G, Shea, YR, Chowdhuri, SR, Rinaldi, MG, Barrett, AJ & Walsh, TJ 2010, 'Pharmacokinetics of liposomal amphotericin B in pleural fluid', Antimicrobial Agents and Chemotherapy, vol. 54, no. 4, pp. 1633-1635. https://doi.org/10.1128/AAC.01438-09
Moriyama B, Torabi-Parizi P, Pratt AK, Henning SA, Pennick G, Shea YR et al. Pharmacokinetics of liposomal amphotericin B in pleural fluid. Antimicrobial Agents and Chemotherapy. 2010 Apr;54(4):1633-1635. https://doi.org/10.1128/AAC.01438-09
Moriyama, Brad ; Torabi-Parizi, Parizad ; Pratt, Alexandra K. ; Henning, Stacey A. ; Pennick, Gennethel ; Shea, Yvonne R. ; Chowdhuri, Sinchita Roy ; Rinaldi, Michael G. ; Barrett, A. John ; Walsh, Thomas J. / Pharmacokinetics of liposomal amphotericin B in pleural fluid. In: Antimicrobial Agents and Chemotherapy. 2010 ; Vol. 54, No. 4. pp. 1633-1635.
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