Pharmacokinetics of liposomal amphotericin B in pleural fluid

Brad Moriyama; Parizad Torabi-Parizi; Alexandra K. Pratt; Stacey A. Henning; Gennethel Pennick; Yvonne R. Shea; Sinchita Roy Chowdhuri; Michael G. Rinaldi; A. John Barrett; Thomas J. Walsh

doi:10.1128/AAC.01438-09

Pharmacokinetics of liposomal amphotericin B in pleural fluid

Brad Moriyama, Parizad Torabi-Parizi, Alexandra K. Pratt, Stacey A. Henning, Gennethel Pennick, Yvonne R. Shea, Sinchita Roy Chowdhuri, Michael G. Rinaldi, A. John Barrett, Thomas J. Walsh

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

We report the penetration of liposomal amphotericin B into the pleural fluid of a patient with pulmonary zygomycosis and empyema. The ratio of area under the concentration-versus-time curve in pleural fluid (AUC _{pleural fluid}) to that in serum (AUC_serum) for liposomal amphotericin B over 24 h was 9.4%, with pleural fluid concentrations of 2.12 to 4.91 μg/ml. Given the relatively low level of intrapleural penetration of liposomal amphotericin B, chest tube drainage may be warranted for successful treatment of zygomycotic empyema.

Original language	English (US)
Pages (from-to)	1633-1635
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	54
Issue number	4
DOIs	https://doi.org/10.1128/AAC.01438-09
State	Published - Apr 2010
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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title = "Pharmacokinetics of liposomal amphotericin B in pleural fluid",

abstract = "We report the penetration of liposomal amphotericin B into the pleural fluid of a patient with pulmonary zygomycosis and empyema. The ratio of area under the concentration-versus-time curve in pleural fluid (AUC pleural fluid) to that in serum (AUCserum) for liposomal amphotericin B over 24 h was 9.4%, with pleural fluid concentrations of 2.12 to 4.91 μg/ml. Given the relatively low level of intrapleural penetration of liposomal amphotericin B, chest tube drainage may be warranted for successful treatment of zygomycotic empyema.",

author = "Brad Moriyama and Parizad Torabi-Parizi and Pratt, {Alexandra K.} and Henning, {Stacey A.} and Gennethel Pennick and Shea, {Yvonne R.} and Chowdhuri, {Sinchita Roy} and Rinaldi, {Michael G.} and Barrett, {A. John} and Walsh, {Thomas J.}",

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AU - Moriyama, Brad

AU - Torabi-Parizi, Parizad

AU - Pratt, Alexandra K.

AU - Henning, Stacey A.

AU - Pennick, Gennethel

AU - Shea, Yvonne R.

AU - Chowdhuri, Sinchita Roy

AU - Rinaldi, Michael G.

AU - Barrett, A. John

AU - Walsh, Thomas J.

PY - 2010/4

Y1 - 2010/4

N2 - We report the penetration of liposomal amphotericin B into the pleural fluid of a patient with pulmonary zygomycosis and empyema. The ratio of area under the concentration-versus-time curve in pleural fluid (AUC pleural fluid) to that in serum (AUCserum) for liposomal amphotericin B over 24 h was 9.4%, with pleural fluid concentrations of 2.12 to 4.91 μg/ml. Given the relatively low level of intrapleural penetration of liposomal amphotericin B, chest tube drainage may be warranted for successful treatment of zygomycotic empyema.

AB - We report the penetration of liposomal amphotericin B into the pleural fluid of a patient with pulmonary zygomycosis and empyema. The ratio of area under the concentration-versus-time curve in pleural fluid (AUC pleural fluid) to that in serum (AUCserum) for liposomal amphotericin B over 24 h was 9.4%, with pleural fluid concentrations of 2.12 to 4.91 μg/ml. Given the relatively low level of intrapleural penetration of liposomal amphotericin B, chest tube drainage may be warranted for successful treatment of zygomycotic empyema.

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Pharmacokinetics of liposomal amphotericin B in pleural fluid

Abstract

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