Pharmacokinetics of anidulafungin in pleural fluid during the treatment of a patient with Candida empyema

Brad Moriyama, Marisa Ditullio, Eleanor Wilson, Stacey A. Henning, Scott R. Penzak, Robert L. Danner, Gennethel Pennick, Michael G. Rinaldi, Adrian M. Zelazny, Juan Gea-Banacloche, A. John Barrett, Thomas J. Walsh

Research output: Contribution to journalArticle

Abstract

Candida empyema is a serious complication of disseminated candidiasis. However, little is known about the intrapleural pharmacokinetics of echinocandins. We report the penetration of anidulafungin into the pleural fluid of a patient with Candida tropicalis empyema. The anidulafungin ratio for the area under the concentration-time curve from 0 h to the last measurement between pleural fluid and serum values was only 0.125 (12.5%), with pleural fluid concentrations ranging between 0.67 and 0.88 μg/ml.

Original languageEnglish (US)
Pages (from-to)2478-2480
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume55
Issue number5
DOIs
StatePublished - May 1 2011

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Moriyama, B., Ditullio, M., Wilson, E., Henning, S. A., Penzak, S. R., Danner, R. L., Pennick, G., Rinaldi, M. G., Zelazny, A. M., Gea-Banacloche, J., Barrett, A. J., & Walsh, T. J. (2011). Pharmacokinetics of anidulafungin in pleural fluid during the treatment of a patient with Candida empyema. Antimicrobial agents and chemotherapy, 55(5), 2478-2480. https://doi.org/10.1128/AAC.01560-10