Abstract
Oral administration of ceftriaxone associated with a bile acid-based new oral carrier, cholylethylenediamine, in 50% propylene glycol to rats at doses of 25 and 50 mg/kg of body weight resulted in a significant increase in intestinal absorption, as evidenced by 55% improvement in the bioavailability, whereas ceftriaxone alone showed a bioavailability of less than 1%.
Original language | English (US) |
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Pages (from-to) | 1869-1871 |
Number of pages | 3 |
Journal | Antimicrobial agents and chemotherapy |
Volume | 50 |
Issue number | 5 |
DOIs | |
State | Published - May 2006 |
Externally published | Yes |
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases