Pharmacokinetics of a new, orally available ceftriaxone formulation in physical complexation with a cationic analogue of bile acid in rats

Seulki Lee, Sang Kyoon Kim, Dong Yun Lee, Su Young Chae, Youngro Byun

Research output: Contribution to journalArticlepeer-review

Abstract

Oral administration of ceftriaxone associated with a bile acid-based new oral carrier, cholylethylenediamine, in 50% propylene glycol to rats at doses of 25 and 50 mg/kg of body weight resulted in a significant increase in intestinal absorption, as evidenced by 55% improvement in the bioavailability, whereas ceftriaxone alone showed a bioavailability of less than 1%.

Original languageEnglish (US)
Pages (from-to)1869-1871
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume50
Issue number5
DOIs
StatePublished - May 2006
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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