Pharmacokinetics and antipruritic effects of hydroxyzine in children with atopic dermatitis

Paul S. Lietman, F. Estelle, R. Simons, Keith J. Simons, Allan B. Becker, Richard P. Haydey

Research output: Contribution to journalArticle

Abstract

We studied the pharmacokinetics and antipruritic effects of hydroxyzine hydrochloride in 12 children, mean age 6.1±4.6 years, with severe atopic dermatitis. After a single 0.7 mg/kg orally administered dose of the drug, the mean peak serum hydroxyzine concentration of 47.4±17.3 ng/ml occurred at a mean time of 2.0±0.9 hours. The mean elimination half-life was 7.1±2.3 hours, the mean clearance rate was 32.08±11.05 ml/min/kg, and the mean apparent volume of distribution was 18.5±8.6 L/kg. The elimination half-life increased with increasing age (r=0.83). Pruritus was significantly suppressed from 1 to 24 hours after the administration of the dose, with greater than 85% suppression from 2 to 12 hours. The only adverse effect reported was sedation. In a subsequent double-blind, crossover, multiple-dose study of 2 weeks' duration, hydroxyzine 0.7 mg/kg three times daily was as effective as hydroxyzine 1.4 mg/kg three times daily in relieving pruritus and promoting resolution of the skin lesions. The 0.7 mg/kg tid dose caused significantly less sedation than the 1.4 mg/kg tid dose.

Original languageEnglish (US)
Pages (from-to)123-127
Number of pages5
JournalThe Journal of pediatrics
Volume104
Issue number1
DOIs
StatePublished - Jan 1984

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Lietman, P. S., Estelle, F., Simons, R., Simons, K. J., Becker, A. B., & Haydey, R. P. (1984). Pharmacokinetics and antipruritic effects of hydroxyzine in children with atopic dermatitis. The Journal of pediatrics, 104(1), 123-127. https://doi.org/10.1016/S0022-3476(84)80608-3