Pharmacokinetic studies on Ro 15-1788, a benzodiazepine receptor ligand, in the brain of the rat

Richard G. Lister; David J. Greenblatt; Darrell R. Abernethy; Sandra E. File

doi:10.1016/0006-8993(84)90752-2

Pharmacokinetic studies on Ro 15-1788, a benzodiazepine receptor ligand, in the brain of the rat

Richard G. Lister, David J. Greenblatt, Darrell R. Abernethy, Sandra E. File

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Abstract

Methods for determining Ro 15-1788 in brain tissue were developed using gas chromatography with nitrogen-phosphorus detection, and using reverse-phase high performance liquid chromatography. Application of the methods to pharmacokinetic studies in the rat found the elimination half-life of Ro 15-1788 from rat brain to be 16 min. Ro 15-1788 was undetectable in rat plasma at the time points studied. Concentrations of Ro 15-1788 in the brain were reduced if chlordiazepoxide was coadministered.

Original language	English (US)
Pages (from-to)	183-186
Number of pages	4
Journal	Brain research
Volume	290
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(84)90752-2
State	Published - Jan 2 1984
Externally published	Yes

Keywords

Ro 15-1788
benzodiazepine
brain
pharmacokinetics
rat

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(84)90752-2

Cite this

@article{715dd131cc90426a959b5be4f673acb8,

title = "Pharmacokinetic studies on Ro 15-1788, a benzodiazepine receptor ligand, in the brain of the rat",

abstract = "Methods for determining Ro 15-1788 in brain tissue were developed using gas chromatography with nitrogen-phosphorus detection, and using reverse-phase high performance liquid chromatography. Application of the methods to pharmacokinetic studies in the rat found the elimination half-life of Ro 15-1788 from rat brain to be 16 min. Ro 15-1788 was undetectable in rat plasma at the time points studied. Concentrations of Ro 15-1788 in the brain were reduced if chlordiazepoxide was coadministered.",

keywords = "Ro 15-1788, benzodiazepine, brain, pharmacokinetics, rat",

author = "Lister, {Richard G.} and Greenblatt, {David J.} and Abernethy, {Darrell R.} and File, {Sandra E.}",

note = "Funding Information: R.G.L. is supported by a School of Pharmacy post-graduate award. D.J.G. and D.R.A. are supported by Grants MH-34223 and AM-32050 from the United States Public Health Service. S.E.F. is a Wellcome Trust senior lecturer. The authors are grateful for the assistance of Dr. Richard I. Shader. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1984",

month = jan,

day = "2",

doi = "10.1016/0006-8993(84)90752-2",

language = "English (US)",

volume = "290",

pages = "183--186",

journal = "Brain research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Pharmacokinetic studies on Ro 15-1788, a benzodiazepine receptor ligand, in the brain of the rat

AU - Lister, Richard G.

AU - Greenblatt, David J.

AU - Abernethy, Darrell R.

AU - File, Sandra E.

N1 - Funding Information: R.G.L. is supported by a School of Pharmacy post-graduate award. D.J.G. and D.R.A. are supported by Grants MH-34223 and AM-32050 from the United States Public Health Service. S.E.F. is a Wellcome Trust senior lecturer. The authors are grateful for the assistance of Dr. Richard I. Shader. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1984/1/2

Y1 - 1984/1/2

N2 - Methods for determining Ro 15-1788 in brain tissue were developed using gas chromatography with nitrogen-phosphorus detection, and using reverse-phase high performance liquid chromatography. Application of the methods to pharmacokinetic studies in the rat found the elimination half-life of Ro 15-1788 from rat brain to be 16 min. Ro 15-1788 was undetectable in rat plasma at the time points studied. Concentrations of Ro 15-1788 in the brain were reduced if chlordiazepoxide was coadministered.

AB - Methods for determining Ro 15-1788 in brain tissue were developed using gas chromatography with nitrogen-phosphorus detection, and using reverse-phase high performance liquid chromatography. Application of the methods to pharmacokinetic studies in the rat found the elimination half-life of Ro 15-1788 from rat brain to be 16 min. Ro 15-1788 was undetectable in rat plasma at the time points studied. Concentrations of Ro 15-1788 in the brain were reduced if chlordiazepoxide was coadministered.

KW - Ro 15-1788

KW - benzodiazepine

KW - brain

KW - pharmacokinetics

KW - rat

UR - http://www.scopus.com/inward/record.url?scp=0021335399&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021335399&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(84)90752-2

DO - 10.1016/0006-8993(84)90752-2

M3 - Article

C2 - 6419985

AN - SCOPUS:0021335399

SN - 0006-8993

VL - 290

SP - 183

EP - 186

JO - Brain research

JF - Brain research

IS - 1

ER -

Pharmacokinetic studies on Ro 15-1788, a benzodiazepine receptor ligand, in the brain of the rat

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this