Pharmacokinetic studies on Ro 15-1788, a benzodiazepine receptor ligand, in the brain of the rat

Richard G. Lister, David J. Greenblatt, Darrell R. Abernethy, Sandra E. File

Research output: Contribution to journalArticlepeer-review

Abstract

Methods for determining Ro 15-1788 in brain tissue were developed using gas chromatography with nitrogen-phosphorus detection, and using reverse-phase high performance liquid chromatography. Application of the methods to pharmacokinetic studies in the rat found the elimination half-life of Ro 15-1788 from rat brain to be 16 min. Ro 15-1788 was undetectable in rat plasma at the time points studied. Concentrations of Ro 15-1788 in the brain were reduced if chlordiazepoxide was coadministered.

Original languageEnglish (US)
Pages (from-to)183-186
Number of pages4
JournalBrain research
Volume290
Issue number1
DOIs
StatePublished - Jan 2 1984

Keywords

  • Ro 15-1788
  • benzodiazepine
  • brain
  • pharmacokinetics
  • rat

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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