Pharmacokinetic studies of prednisolone in children. Plasma levels, half-life values, and correlation with physiologic assays for growth and immunity

Orville C. Green, Robert J. Winter, Frank S. Kawahara, Lawrence S. Phillips, Peter R. Lewy, Robert L. Hart, Lauren M. Pachman, Paul S. Lietman

Research output: Contribution to journalArticlepeer-review

Abstract

Plasma prednisolone levels have been measured hourly in children receiving a single dose of oral prednisone. Peak prednisolone levels occurred one to two hours after ingestion; half-life studies gave a mean value of 132 minutes in most children. Some children had marked variability in absorption and metabolism of prednisone. Somatomedin activity and cell-mediated immunity were inhibited by plasma prednisolone values which were achieved by single doses of prednisone of 0.5 mg/kg or higher. Monitoring prednisolone levels may be value in identifying those children who accumulate excessively high levels on moderate dosage regimens.

Original languageEnglish (US)
Pages (from-to)299-303
Number of pages5
JournalThe Journal of pediatrics
Volume93
Issue number2
DOIs
StatePublished - Aug 1978

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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