### Abstract

Vitreous fluorophotometry is producing an increasing amount of clinical and experimental data. In order to interpret these data and obtain quantitative values for the permeability of the blood ocular barriers, there is a need to understand better the basic phenomena governing the transport of fluorescein. We present here a refined mathematical model that we use to interpret a large body of clinical data yielding values for the inward (6.9 x 10^{-6} cm/min) and outward (210 x 10^{-6} cm/min) posterior permeability coefficients, the effective diffusion coefficient in the vitreous (8 x 10^{-4} cm^{2}/min), and the plasma fluorescein decay constants (1.17, 0.34, and 0.044 per hour). Moreover, we utilize the model to make predictions related to kinetic vitreous fluorophotometry and to the reliability of the procedure to calculate the permeability coefficients.

Original language | English (US) |
---|---|

Pages (from-to) | 1374-1381 |

Number of pages | 8 |

Journal | Investigative Ophthalmology and Visual Science |

Volume | 24 |

Issue number | 10 |

State | Published - 1983 |

Externally published | Yes |

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### ASJC Scopus subject areas

- Ophthalmology

### Cite this

*Investigative Ophthalmology and Visual Science*,

*24*(10), 1374-1381.

**Pharmacokinetic interpretation of vitreous fluorophotometry.** / Zeimer, Ran; Blair, N. P.; Cunha Vaz, J. G.

Research output: Contribution to journal › Article

*Investigative Ophthalmology and Visual Science*, vol. 24, no. 10, pp. 1374-1381.

}

TY - JOUR

T1 - Pharmacokinetic interpretation of vitreous fluorophotometry

AU - Zeimer, Ran

AU - Blair, N. P.

AU - Cunha Vaz, J. G.

PY - 1983

Y1 - 1983

N2 - Vitreous fluorophotometry is producing an increasing amount of clinical and experimental data. In order to interpret these data and obtain quantitative values for the permeability of the blood ocular barriers, there is a need to understand better the basic phenomena governing the transport of fluorescein. We present here a refined mathematical model that we use to interpret a large body of clinical data yielding values for the inward (6.9 x 10-6 cm/min) and outward (210 x 10-6 cm/min) posterior permeability coefficients, the effective diffusion coefficient in the vitreous (8 x 10-4 cm2/min), and the plasma fluorescein decay constants (1.17, 0.34, and 0.044 per hour). Moreover, we utilize the model to make predictions related to kinetic vitreous fluorophotometry and to the reliability of the procedure to calculate the permeability coefficients.

AB - Vitreous fluorophotometry is producing an increasing amount of clinical and experimental data. In order to interpret these data and obtain quantitative values for the permeability of the blood ocular barriers, there is a need to understand better the basic phenomena governing the transport of fluorescein. We present here a refined mathematical model that we use to interpret a large body of clinical data yielding values for the inward (6.9 x 10-6 cm/min) and outward (210 x 10-6 cm/min) posterior permeability coefficients, the effective diffusion coefficient in the vitreous (8 x 10-4 cm2/min), and the plasma fluorescein decay constants (1.17, 0.34, and 0.044 per hour). Moreover, we utilize the model to make predictions related to kinetic vitreous fluorophotometry and to the reliability of the procedure to calculate the permeability coefficients.

UR - http://www.scopus.com/inward/record.url?scp=0020606553&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020606553&partnerID=8YFLogxK

M3 - Article

C2 - 6618797

AN - SCOPUS:0020606553

VL - 24

SP - 1374

EP - 1381

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

SN - 0146-0404

IS - 10

ER -