Pharmacokinetic interactions between buprenorphine/naloxone and raltegravir in subjects receiving chronic buprenorphine/naloxone treatment

R. Douglas Bruce, David E. Moody, Diane Chodkowski, Laurie Andrews, Wenfang B. Fang, Jerdravee Morrison, Theresa L. Parsons, Gerald H. Friedland

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Interactions between human immuno-deficiency virus (HIV) and opioid-dependence therapies can occur. Objectives: We sought to determine whether such interactions occurred between buprenorphine/naloxone and raltegravir. Methods: We performed a within-subject open-labeled pharmacokinetic and pharmacodynamic study in 12 HIV-seronegative subjects stabilized on at least 3 weeks of buprenorphine/naloxone therapy. Subjects underwent baseline and steady-state evaluation of the effect of raltegravir 400 mg BID on buprenorphine/naloxone parameters. Results: Compared with baseline values, buprenorphine AUC0-24 h (58.2 vs. 56.0 hr*ng/mL) and Cmax (7.37 vs. 6.60 ng/mL) did not differ significantly after achieving steady-state raltegravir. Similar analyses of norbuprenorphine, the primary metabolite of buprenorphine, demonstrated no significant difference after raltegravir administration. Naloxone concentrations were unchanged for AUC0-24 h (.595 vs. .581 hr*ng/mL), Cmax (.251 vs. .243 ng/mL) and Tmax (.75 vs.1.08 h). Objective opioid withdrawal was not observed. The AUC0-12 h and Cmax of raltegravir did not significantly differ from historical controls (5543 vs. 4428 h*ng/mL and 1070 vs. 1266 ng/mL), respectively. Conclusion: The addition of raltegravir to stabilized patients receiving buprenorphine/naloxone does not significantly affect buprenorphine/naloxone or raltegravir pharmacokinetic or pharmacodynamic parameters. Copyrigh

Original languageEnglish (US)
Pages (from-to)80-85
Number of pages6
JournalAmerican Journal of Drug and Alcohol Abuse
Volume39
Issue number2
DOIs
StatePublished - Mar 1 2013

Keywords

  • Buprenorphine/naloxone
  • HIV/AIDS
  • Pharmacokinetics
  • Raltegravir
  • Substance abuse

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Clinical Psychology
  • Psychiatry and Mental health

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