Abstract
Total platinum kinetics were studied after the administration of two formulation products of cisplatin: the lyophilized form and a ready-to-use solution. Twelve patients received both preparations during two successive cycles in a randomized crossover study. Platinum concentrations in plasma and urine were measured by atomic absorption spectrometry. Data were analyzed by means of a mixed-effect analysis of variance. Areas under the concentration-time curves up to 96 h were increased (p = 0.026) and slopes of the elimination phase were decreased (p = 0.035) during cycle 2 when compared with cycle 1. However, no difference in these two parameters was observed when comparing the two formulations. Three-day urinary platinum excretion was not related to either the treatment cycle or the formulation used. Because of its convenience of use and reduced risk of aerosolization, the ready-to-use formulation seems preferable.
Original language | English (US) |
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Pages (from-to) | 264-268 |
Number of pages | 5 |
Journal | Therapeutic Drug Monitoring |
Volume | 8 |
Issue number | 3 |
State | Published - 1986 |
Externally published | Yes |
Keywords
- Cisplatin
- Ready-to-use solution
- Total platinum pharmacokinetics
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Toxicology
- Health, Toxicology and Mutagenesis
- Biochemistry
- General Biochemistry, Genetics and Molecular Biology
- Public Health, Environmental and Occupational Health