Pharmacokinetic comparison of cisplatin in solution with common lyophilized cisplatinum (Platinol)

J. B. Vermorken, W. J. van der Vijgh, I. Klein, H. E. Gall, T. A W Splinter, A. A M Hart, H. M. Pinedo

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Total platinum kinetics were studied after the administration of two formulation products of cisplatin: the lyophilized form and a ready-to-use solution. Twelve patients received both preparations during two successive cycles in a randomized crossover study. Platinum concentrations in plasma and urine were measured by atomic absorption spectrometry. Data were analyzed by means of a mixed-effect analysis of variance. Areas under the concentration-time curves up to 96 h were increased (p = 0.026) and slopes of the elimination phase were decreased (p = 0.035) during cycle 2 when compared with cycle 1. However, no difference in these two parameters was observed when comparing the two formulations. Three-day urinary platinum excretion was not related to either the treatment cycle or the formulation used. Because of its convenience of use and reduced risk of aerosolization, the ready-to-use formulation seems preferable.

Original languageEnglish (US)
Pages (from-to)264-268
Number of pages5
JournalTherapeutic Drug Monitoring
Volume8
Issue number3
StatePublished - 1986
Externally publishedYes

Keywords

  • Cisplatin
  • Ready-to-use solution
  • Total platinum pharmacokinetics

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Toxicology
  • Health, Toxicology and Mutagenesis
  • Biochemistry
  • General Biochemistry, Genetics and Molecular Biology
  • Public Health, Environmental and Occupational Health

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