Abstract
Amphetamine is a common therapeutic agent for alleviating the core symptoms associated with attention-deficit hyperactivity disorder (ADHD) in children and adults. The current study used a translational model of attention, the five-choice serial reaction time (5-CSRT) procedure with rats, to examine the time-course effects of d-amphetamine. Effects of different dosages of d-amphetamine were related to drug-plasma concentrations, fashioned after comprehensive pharmacokinetic/pharmacodynamic assessments that have been employed in clinical investigations. We sought to determine whether acute drug-plasma concentrations that enhance performance in the 5-CSRT procedure are similar to those found to be therapeutic in patients diagnosed with ADHD. Results from the pharmacokinetic/pharmacodynamic assessment indicate that d-amphetamine plasma concentrations associated with improved performance on the 5-CSRT procedure overlap with those that have been reported to be therapeutic in clinical trials. The current findings suggest that the 5-CSRT procedure may be a useful preclinical model for predicting the utility of novel ADHD therapeutics and their effective concentrations.
Original language | English (US) |
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Pages (from-to) | 551-556 |
Number of pages | 6 |
Journal | Behavioural Pharmacology |
Volume | 29 |
Issue number | 6 |
DOIs | |
State | Published - Sep 1 2018 |
Keywords
- attention
- attention-deficit hyperactivity disorder
- d-amphetamine
- five-choice serial reaction time
- pharmacokinetics
- rat
- time course
ASJC Scopus subject areas
- Pharmacology
- Psychiatry and Mental health