[Pharmacogenomics of multiple sclerosis: association of immune response genes polymorphism with copaxone treatment efficacy].

E. I. Tsareva, O. G. Kulakova, O. I. Makarycheva, A. N. Boǐko, S. G. Shchur, N. I. Lashch, N. F. Popova, E. I. Gusev, V. V. Bashinskaia, D. V. L'vov, A. V. Favorov, M. F. Ochs, O. O. Favorova

Research output: Contribution to journalArticle

Abstract

Complex association analysis of copaxone (glatiramer acetate) immunotherapy efficacy with allelic polymorphism in the number of immune response genes, which encode interferone beta (IFNB1), transforming growth factor beta1 (TGFB1), interferone gamma (IFNG), tumor necrosis factor (TNF), interferon alpha/beta receptor 1 (IFNAR1), CC chemokine receptor 5 (CCR5), interleukin 7 receptor alpha subunit (IL7RA), cytotoxic T-lymphocyte antigen 4 (CTLA4) and HLA class II histocompatibility antigen beta chain (DRB1) was performed with APSampler algorithm for 285 multiple sclerosis patients of Russian ethnicity. The results show evidence for the contribution of polymorphic variants in CCRS, DRB1, IFNG, TGFB1, IFNAR1, IL7RA and, probably, TNF and CTLA4 genes to copaxone treatment response. Single alleles of CCR5 and DRB1 genes are reliably associated with treatment efficacy. Carriage of allelic variants of other above mentioned genes contribute with reliable effect to copaxone treatment response as part of bi- and three-allelic combinations only. Present investigation may support basis toward the future possibility of prognostic test realization, which can provide a personal choice of immunomodulatory treatment for a patient with multiple sclerosis.

Original languageEnglish (US)
Pages (from-to)963-972
Number of pages10
JournalMolekuliarnaia biologiia
Volume45
Issue number6
StatePublished - Nov 1 2011
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Tsareva, E. I., Kulakova, O. G., Makarycheva, O. I., Boǐko, A. N., Shchur, S. G., Lashch, N. I., Popova, N. F., Gusev, E. I., Bashinskaia, V. V., L'vov, D. V., Favorov, A. V., Ochs, M. F., & Favorova, O. O. (2011). [Pharmacogenomics of multiple sclerosis: association of immune response genes polymorphism with copaxone treatment efficacy]. Molekuliarnaia biologiia, 45(6), 963-972.