Pharmacogenomics of Antiretroviral Drug Metabolism and Transport

Zaikuan J. Yu, Eric P. Mosher, Namandjé N. Bumpus

Research output: Contribution to journalReview articlepeer-review

Abstract

Antiretroviral therapy has markedly reduced morbidity and mortality for persons living with human immunodeficiency virus (HIV). Individual tailoring of antiretroviral regimens has the potential to further improve the long-term management of HIV through the mitigation of treatment failure and drug-induced toxicities. While the mechanisms underlying anti-HIV drug adverse outcomes are multifactorial, the application of drug-specific pharmacogenomic knowledge is required in order to move toward the personalization of HIV therapy. Thus, detailed understanding of the metabolism and transport of antiretrovirals and the influence of genetics on these pathways is important. To this end, this review provides an up-to-date overview of the metabolism of anti-HIV therapeutics and the impact of genetic variation in drug metabolism and transport on the treatment of HIV. Future perspectives on and current challenges in pursuing personalized HIV treatment are also discussed.

Original languageEnglish (US)
Pages (from-to)565-585
Number of pages21
JournalAnnual Review of Pharmacology and Toxicology
Volume61
DOIs
StatePublished - Jan 6 2021

Keywords

  • HIV medication
  • Pharmacogenomics
  • drug metabolism
  • drug-drug interactions
  • personalized medicine

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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