Pharmacogenomic assessment of Mexican and Peruvian populations

Sharon Marsh, Cristi R. King, Derek J. Van Booven, Jane Y. Revollo, Robert H Gilman, Howard L. McLeod

Research output: Contribution to journalArticle

Abstract

Background: Clinically relevant polymorphisms often demonstrate population-specific allele frequencies. Central and South America remain largely uncategorized in the context of pharmacogenomics. Materials & methods: We assessed 15 polymorphisms from 12 genes (ABCB1 3435C>T, ABCG2 Q141K, CYP1B1∗3, CYP2C19∗2, CYP3A4∗1B, CYP3A5∗3C, ERCC1 N118N, ERCC2 K751Q, GSTP1 I105V, TPMT 238G>C, TPMT 460G>A, TPMT 719A>G, TYMS TSER, UGT1A1∗28 and UGT1A1 -3156G>A) in 81 Peruvian and 95 Mexican individuals. Results: Six polymorphism frequencies differed significantly between the two populations: ABCB1 3435C>T, CYP1B1∗3, GSTP1 I105V, TPMT 460G>A, UGT1A1∗28 and UGT1A1 -3156G>A. The pattern of observed allele frequencies for all polymorphisms could not be accurately estimated from any single previously studied population. Conclusion: This highlights the need to expand the scope of geographic data for use in pharmacogenomics studies.

Original languageEnglish (US)
Pages (from-to)441-448
Number of pages8
JournalPharmacogenomics
Volume16
Issue number5
DOIs
Publication statusPublished - Apr 1 2015

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Keywords

  • Genotype
  • Hispanic
  • Mexico
  • Peru
  • Pharmacogenomics
  • Polymorphism
  • Population

ASJC Scopus subject areas

  • Pharmacology
  • Genetics
  • Molecular Medicine

Cite this

Marsh, S., King, C. R., Van Booven, D. J., Revollo, J. Y., Gilman, R. H., & McLeod, H. L. (2015). Pharmacogenomic assessment of Mexican and Peruvian populations. Pharmacogenomics, 16(5), 441-448. https://doi.org/10.2217/pgs.15.10