Pharmacoepidemiology of Psychotropic Medications in Youth

Daniel J. Safer, Julie Magno Zito

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Large community-based, computerized administrative datasets comprised of enrollment data, socio-demographic characteristics, and diagnostic and treatment information on all individuals in populations or a health insurance plan constitute the major resource for pharmacoepidemiologic research. Investigators use such data to estimate prevalence or new-onset medication use in terms of trends, persistence of use, and the demographic and clinical correlates of treatment. Physician visit data provide diagnoses which can be linked to medication use. This review covers psychotropic medication treatment patterns of U.S. youth over the last 20 years and reveals information very different from the findings derived from clinical trials or case series reports. Pharmacoepidemiologic data are more generalizable to the population at large. Recent trends show that concomitant psychotropic medication regimens, commonly including antipsychotics, have profoundly increased in youth, reflecting substantial off-label usage. Such population-based research can be used to identify and expand the public health mission in pediatric pharmacotherapy.

Original languageEnglish (US)
Title of host publicationPharmacotherapy of Child and Adolescent Psychiatric Disorders: Third Edition
PublisherJohn Wiley and Sons
Pages7-23
Number of pages17
ISBN (Print)9780470973769
DOIs
StatePublished - Feb 17 2012

Fingerprint

Pharmacoepidemiology
Demography
Population
Health Insurance
Research
Antipsychotic Agents
Therapeutics
Public Health
Research Personnel
Clinical Trials
Pediatrics
Physicians
Drug Therapy

Keywords

  • Children
  • Concomitant regimens
  • Drug prevalence
  • Pharmacoepidemiology
  • Psychotropic medication

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Safer, D. J., & Zito, J. M. (2012). Pharmacoepidemiology of Psychotropic Medications in Youth. In Pharmacotherapy of Child and Adolescent Psychiatric Disorders: Third Edition (pp. 7-23). John Wiley and Sons. https://doi.org/10.1002/9781119958338.ch2

Pharmacoepidemiology of Psychotropic Medications in Youth. / Safer, Daniel J.; Zito, Julie Magno.

Pharmacotherapy of Child and Adolescent Psychiatric Disorders: Third Edition. John Wiley and Sons, 2012. p. 7-23.

Research output: Chapter in Book/Report/Conference proceedingChapter

Safer, DJ & Zito, JM 2012, Pharmacoepidemiology of Psychotropic Medications in Youth. in Pharmacotherapy of Child and Adolescent Psychiatric Disorders: Third Edition. John Wiley and Sons, pp. 7-23. https://doi.org/10.1002/9781119958338.ch2
Safer DJ, Zito JM. Pharmacoepidemiology of Psychotropic Medications in Youth. In Pharmacotherapy of Child and Adolescent Psychiatric Disorders: Third Edition. John Wiley and Sons. 2012. p. 7-23 https://doi.org/10.1002/9781119958338.ch2
Safer, Daniel J. ; Zito, Julie Magno. / Pharmacoepidemiology of Psychotropic Medications in Youth. Pharmacotherapy of Child and Adolescent Psychiatric Disorders: Third Edition. John Wiley and Sons, 2012. pp. 7-23
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