Pharmacoepidemiology in the postmarketing assessment of the safety and efficacy of drugs in older adults

Sarah N. Hilmer, Danijela Gnjidic, Darrell R. Abernethy

Research output: Contribution to journalArticlepeer-review

Abstract

Much of the information on safety and efficacy of drugs in older people is obtained after marketing. Pharmacoepidemiologic studies play an increasing role in obtaining this information. Pharmacoepidemiologic studies contribute significantly to knowledge of risks associated with medicines in older people and less so to that of benefits. Recent improvements in methodology in both pharmacoepidemiology and geriatric medicine have improved the validity and reduced the bias of these studies. Pharmacoepidemiologic studies are a critical component of assessing the risks of medicines in older people. Where possible, findings of pharmacoepidemiologic studies should be tested with well-conducted interventional randomized trials in relevant populations of older people.

Original languageEnglish (US)
Pages (from-to)181-188
Number of pages8
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume67 A
Issue number2
DOIs
StatePublished - Feb 2012

Keywords

  • Drug safety and efficacy
  • Older adults
  • Pharmacoepidemiology

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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