PH responsive fluorescence nanoprobe imaging of tumors by sensing the acidic microenvironment

Lu Wang, Cong Li

Research output: Contribution to journalArticle

Abstract

Optical imaging is promising in tumor diagnosis due to its high sensitivity, no radioactive irradiation and low running cost. Compared to small molecular probes, fluorescence nanoprobes demonstrate a tunable circulation lifetime, an up-regulated intratumoral accumulation and enhanced sensitivity by labeling multiple imaging reporters on a single nanoparticle. Acidic extracellular fluid is a universal phenomenon of solid tumors. Therefore, a nanoprobe that responds to the acidic microenvironment is promising in visualizing a tumor in vivo, regardless of the tumor type or even developmental stage. Moreover, the fluorescence "activation" in the tumor but not the normal tissues will greatly increase the "target to background" signal ratio, which benefits the visualization of small volume tumors with high sensitivity. In this review, we summarize the recent developments in pH responsive fluorescence nanoprobes for tumor visualization.

Original languageEnglish (US)
Pages (from-to)15862-15871
Number of pages10
JournalJournal of Materials Chemistry
Volume21
Issue number40
DOIs
StatePublished - Oct 28 2011
Externally publishedYes

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Nanoprobes
Tumors
Fluorescence
Imaging techniques
Visualization
Molecular Probes
Labeling
Chemical activation
Irradiation
Tissue
Nanoparticles
Fluids

ASJC Scopus subject areas

  • Materials Chemistry
  • Chemistry(all)

Cite this

PH responsive fluorescence nanoprobe imaging of tumors by sensing the acidic microenvironment. / Wang, Lu; Li, Cong.

In: Journal of Materials Chemistry, Vol. 21, No. 40, 28.10.2011, p. 15862-15871.

Research output: Contribution to journalArticle

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